Selective generation of gut-tropic T cells in gut-associated lymphoid tissues: requirement for GALT dendritic cells and adjuvant.

Annals of the New York Academy of Sciences ·Vol. 1029 ·2004-12-00 ·Pages 405-7

Svensson M, Johansson-Lindbom B, Wurbel MA, Malissen B, Márquez G, Agace W

Abstract

To gain entry into peripheral tissues, effector T lymphocytes express specific combinations of adhesion molecules and chemokine receptors. Expression of these are induced during activation in regional secondary lymphoid organs. Herein, we describe a role for GALT DCs in the generation of CCR9(+) alpha(4)beta(7)(+) gut tropic lymphocytes.

MeSH Terms

Animals Antigen-Presenting Cells/immunology Chemokines/immunology Dendritic Cells/immunology Humans Immunity, Mucosal Inflammation/immunology Intestinal Mucosa/immunology Lymphoid Tissue/immunology Receptors, Lymphocyte Homing/immunology T-Lymphocytes/immunology

Chemicals

Chemokines Receptors, Lymphocyte Homing

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Svensson Marcus

Immunology Section, Lund University, BMC I-13, S-22184 Lund, Sweden. Marcus.Svensson@immuno.lu.se

Johansson-Lindbom Bengt

Wurbel Marc-André

Malissen Bernard

Márquez Gabriel

Agace William

Article Info

Journal

Annals of the New York Academy of Sciences

Abbr.

Ann N Y Acad Sci

ISSN

0077-8923

DOI

10.1196/annals.1309.025

marcus.svensson@immuno.lu.se

Published

2004-12-00

Pages

405-7

Language

English

Region

United States

NLM ID

7506858

Subset

External Links

PubMed source DOI: 10.1196/annals.1309.025 View journal details

Analysis Services

Selective generation of gut-tropic T cells in gut-associated lymphoid tissues: requirement for GALT dendritic cells and adjuvant.

Contact

WeChat Official Account