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PMID: 15653505 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Anticonvulsant medications extend worm life-span.

Science (New York, N.Y.) ·Vol. 307 ·No. 5707 ·2005-01-14 ·Pages 258-62

Evason K, Huang C, Yamben I, Covey DF, Kornfeld K

Abstract

Genetic studies have elucidated mechanisms that regulate aging, but there has been little progress in identifying drugs that delay aging. Here, we report that ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes, indicating that these compounds retard the aging process. These compounds, two of which are approved for human use, are anticonvulsants that modulate neural activity. These compounds also regulated neuromuscular activity in nematodes. These findings suggest that the life-span-extending activity of these compounds is related to the anticonvulsant activity and implicate neural activity in the regulation of aging.

MeSH Terms

Aging/drug effects Aldicarb/pharmacology Animals Anticonvulsants/pharmacology,therapeutic use Caenorhabditis elegans/drug effects,genetics,growth & development,physiology Caenorhabditis elegans Proteins/genetics,physiology Disorders of Sex Development Dose-Response Relationship, Drug Drug Evaluation, Preclinical Epilepsy, Absence/drug therapy Ethosuximide/pharmacology,therapeutic use Female Forkhead Transcription Factors Genes, Helminth Humans Lactams/pharmacology Longevity/drug effects Movement/drug effects Muscles/drug effects,innervation,physiology Mutation Neurons/drug effects,physiology Oviposition/drug effects Pharynx/drug effects,physiology Reproduction/drug effects Synaptic Transmission/drug effects Transcription Factors/genetics,physiology Trimethadione/pharmacology,therapeutic use Vulva

Chemicals

3,3-diethyl-2-pyrrolidinone Anticonvulsants Caenorhabditis elegans Proteins Forkhead Transcription Factors Lactams Transcription Factors daf-16 protein, C elegans Ethosuximide Aldicarb Trimethadione

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Evason Kimberley

Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Huang Cheng

Yamben Idella

Covey Douglas F

Kornfeld Kerry

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

1095-9203

DOI

10.1126/science.1105299

Published

2005-01-14

Pages

258-62

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NIA NIH HHS · P50 AG05681 · United States

Corrections

CommentIn

PMID: 15653476

External Links

PubMed source DOI: 10.1126/science.1105299 View journal details

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Anticonvulsant medications extend worm life-span.

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