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PMID: 15643447 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Postsynaptic scaffold proteins at non-synaptic sites. The role of postsynaptic scaffold proteins in motor-protein-receptor complexes.

EMBO reports ·Vol. 6 ·No. 1 ·2005-01-00 ·Pages 22-7

Kneussel M

Abstract

Synapse-associated proteins that are located at the postsynaptic density (PSD) have recently been shown to have a structural role at non-synaptic locations. Here, they act as adaptor proteins between neurotransmitter receptors and the microtubule- or microfilament-based motor-protein complexes that are responsible for transport to the PSD. The use of a common set of proteins that contain multiple domains for protein-protein interactions as both intracellular transport adaptors and synaptic scaffold proteins might contribute to the transport specificity and postsynaptic integration of receptors that underlie synapse formation and plasticity.

MeSH Terms
Animals Microtubules/metabolism Neurons/metabolism Protein Transport Synapses/chemistry,metabolism
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kneussel Matthias
Zentrum für Molekulare Neurobiologie Hamburg, ZMNH, Universität Hamburg, Falkenried 94, D-20251 Hamburg, Germany. matthias.kneussel@zmnh.uni-hamburg.de
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Article Info
Journal
EMBO reports
Abbr.
EMBO Rep
ISSN
1469-221X
DOI
10.1038/sj.embor.7400319
Email
matthias.kneussel@zmnh.uni-hamburg.de
Published
2005-01-00
Pages
22-7
Language
English
Region
England
NLM ID
100963049
PMCID
PMC1299229
Subset
IM
External Links
PubMed source DOI: 10.1038/sj.embor.7400319 PMC Full Text View journal details
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