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PMID: 15640804 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141.

Nature immunology ·Vol. 6 ·No. 2 ·2005-02-00 ·Pages 181-8

Tomasec P, Wang EC, Davison AJ, Vojtesek B, Armstrong M, Griffin C, McSharry BP, Morris RJ, Llewellyn-Lacey S, Rickards C, Nomoto A, Sinzger C, Wilkinson GW

Abstract

Natural killer (NK) cells are crucial in the control of cytomegalovirus infections in mice and humans. Here we show that the viral UL141 gene product has an immunomodulatory function that is associated with low-passage strains of human cytomegalovirus. UL141 mediated efficient protection of cells against killing by a wide range of human NK cell populations, including interferon-alpha-stimulated bulk cultures, polyclonal NK cell lines and most NK cell clones tested. Evasion of NK cell killing was mediated by UL141 blocking surface expression of CD155, which was previously identified as a ligand for NK cell-activating receptors CD226 (DNAM-1) and CD96 (TACTILE). The breadth of the UL141-mediated effect indicates that CD155 has a key role in regulating NK cell function.

MeSH Terms
Cells, Cultured Cytomegalovirus/physiology Cytomegalovirus Infections/immunology,metabolism,virology Down-Regulation Glycoproteins/genetics,metabolism Humans Killer Cells, Natural/immunology,metabolism,virology Ligands Membrane Proteins/immunology,metabolism Mutation/genetics Receptors, Virus/immunology,metabolism Viral Proteins/genetics,metabolism
Chemicals
Glycoproteins Ligands Membrane Proteins Receptors, Virus Viral Proteins poliovirus receptor
Authors & Affiliations
13 authors, click to expand affiliations / ORCID
Tomasec Peter
Section of Infection and Immunity, Tenovus Building, College of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XX, UK.
Wang Eddie C Y
Davison Andrew J
Vojtesek Borivoj
Armstrong Melanie
Griffin Cora
McSharry Brian P
Morris Rebecca J
Llewellyn-Lacey Sian
Rickards Carole
Nomoto Akio
Sinzger Christian
Wilkinson Gavin W G
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Article Info
Journal
Nature immunology
Abbr.
Nat Immunol
ISSN
1529-2908
DOI
10.1038/ni1156
Published
2005-02-00
Epub
2005-00-09
Pages
181-8
Language
English
Region
United States
NLM ID
100941354
PMCID
PMC2844263
Subset
IM
Grants
Medical Research Council · G0300180 · United Kingdom
Medical Research Council · G0300180(65735) · United Kingdom
Medical Research Council · G0500617(74644) · United Kingdom
Wellcome Trust · 066749 · United Kingdom
Medical Research Council · G0500617 · United Kingdom
Medical Research Council · G9827961 · United Kingdom
External Links
PubMed source DOI: 10.1038/ni1156 PMC Full Text View journal details
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