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PMID: 15637738 Published · ppublish English Journal Article Meta-Analysis Research Support, Non-U.S. Gov't

Relationship between metabolic enzyme polymorphism and colorectal cancer.

World journal of gastroenterology ·Vol. 11 ·No. 3 ·2005-01-21 ·Pages 331-5

Chen K, Jiang QT, He HQ

Abstract

To clarify the influence of genetic polymorphisms on colorectal cancer. The results of 42 related studies from 1990 to 2001 were analyzed by meta-analysis. Mantel-Haenzel fixed-effect model or Dersimonian-Laird random-effect model and ReviewManager 4.1 statistical program were applied in processing the data. Meta analysis of these studies showed that GSTT1 deletion (pooled OR = 1.42), N-acetyltransferase 2 (NAT2)-rapid acetylator phenotype and genotye (pooled OR = 1.08) and NAT2-rapid acetylator phenotype (pooled OR = 1.15) had a significantly increased risk for colorectal cancer (P<0.05), other genotypes like GSTM1 deletion, GSTP1 1le105Val, NAT1*10, NAT2-rapid acetylator genotype CYP1A1 L1e462Val, CYP1A1 MspI*C, MTHFR C677T and MTR A2759G had no significant relationship with colorectal cancer (P>0.05). Risks for colorectal cancer are significantly associated with the genetic polymorphisms of GSTT1 deletion, NAT2-rapid acetylator phenotype and genotye and NAT2-rapid acetylator phenotype.

MeSH Terms
Arylamine N-Acetyltransferase/genetics Colorectal Neoplasms/genetics Gene Deletion Genetic Predisposition to Disease Genotype Glutathione Transferase/genetics Humans Phenotype Polymorphism, Genetic
Chemicals
Arylamine N-Acetyltransferase NAT2 protein, human glutathione S-transferase T1 Glutathione Transferase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Chen Kun
Department of Epidemiology and Health Statistics, School of Medicine, Zhejiang University, Hangzhou 310031, Zhejiang Province, China. ck@zju.edu.cn
Jiang Qin-Ting
He Han-Qing
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Article Info
Journal
World journal of gastroenterology
Abbr.
World J Gastroenterol
ISSN
1007-9327
DOI
10.3748/wjg.v11.i3.331
Email
ck@zju.edu.cn
Published
2005-01-21
Pages
331-5
Language
English
Region
United States
NLM ID
100883448
PMCID
PMC4205331
Subset
IM
External Links
PubMed source DOI: 10.3748/wjg.v11.i3.331 PMC Full Text View journal details
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