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PMID: 15630451 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors.

The Journal of clinical investigation ·Vol. 115 ·No. 1 ·2005-01-00 ·Pages 118-27

Li X, Tjwa M, Moons L, Fons P, Noel A, Ny A, Zhou JM, Lennartsson J, Li H, Luttun A, Pontén A, Devy L, Bouché A, Oh H, Manderveld A, Blacher S, Communi D, Savi P, Bono F, Dewerchin M, Foidart JM, Autiero M, Herbert JM, Collen D, Heldin CH, Eriksson U, Carmeliet P

Abstract

The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.

MeSH Terms
Animals Cell Differentiation/drug effects Cell Movement/drug effects Cells, Cultured Coronary Vessels/cytology,drug effects Endothelial Cells/cytology,drug effects Hindlimb/blood supply,drug effects Humans Ischemia/chemically induced,drug therapy,metabolism,pathology Lymphokines Mice Microcirculation/drug effects Myocardium/metabolism,pathology Neovascularization, Physiologic/drug effects Phosphotyrosine/metabolism Platelet-Derived Growth Factor/pharmacology Receptors, Platelet-Derived Growth Factor/metabolism Signal Transduction Stem Cells/cytology,drug effects
Chemicals
Lymphokines Platelet-Derived Growth Factor platelet-derived growth factor C Phosphotyrosine Receptors, Platelet-Derived Growth Factor
Authors & Affiliations
27 authors, click to expand affiliations / ORCID
Li Xuri
The Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology (VIB), University of Leuven, Leuven, Belgium.
Tjwa Marc
Moons Lieve
Fons Pierre
Noel Agnes
Ny Annelii
Zhou Jian Min
Lennartsson Johan
Li Hong
Luttun Aernout
Pontén Annica
Devy Laetitia
Bouché Ann
Oh Hideyasu
Manderveld Ann
Blacher Silvia
Communi David
Savi Pierre
Bono Françoise
Dewerchin Mieke
Foidart Jean-Michel
Autiero Monica
Herbert Jean-Marc
Collen D
Heldin Carl-Henrik
Eriksson Ulf
Carmeliet Peter
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI19189
Published
2005-01-00
Pages
118-27
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC535797
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI19189 PMC Full Text View journal details
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