| GeneLibs

题目:: A germ cell origin of embryonic stem cells?
作者:: Zwaka(Thomas P),Thomson(James A)
状态:: 发布时间2004-12-29 , 更新时间 2007-11-15
期刊:: Development
摘要:: Because embryonic stem (ES) cells are generally derived by the culture of inner cell mass (ICM) cells, they are often assumed to be the equivalent of ICM cells. However, various evidence indicates that ICM cells transition to a different cell type during ES-cell derivation. Historically, ES cells have been believed to most closely resemble pluripotent primitive ectoderm cells derived directly from the ICM. However, differences between ES cells and primitive ectoderm cells have caused developmental biologists to question whether ES cells really have an in vivo equivalent, or whether their properties merely reflect their tissue culture environment. Here, we review recent evidence that the closest in vivo equivalent of an ES cell is an early germ cell.
语言:: eng
DOI:: 10.1242/dev.01586

文献库文献相关信息