Neuroblastoma update.

The purpose of this paper is to review the most recent medical literature pertaining to neuroblastoma. Clinically, progress continues to be made on the refinement of radiographic staging and risk stratification-based treatment. Meanwhile, experimental efforts focus on the continued search for biologic prognostic markers and the development of novel therapies including second-generation retinoids, tumor vaccines, and new modes of drug delivery with improved safety and efficacy. Review of the recent neuroblastoma literature demonstrates continued progress in our ability to understand and treat this enigmatic tumor.