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PMID: 15604411 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS.

Science (New York, N.Y.) ·Vol. 306 ·No. 5704 ·2004-12-17 ·Pages 2111-5

Arnett HA, Fancy SP, Alberta JA, Zhao C, Plant SR, Kaing S, Raine CS, Rowitch DH, Franklin RJ, Stiles CD

Abstract

Olig1 and Olig2 are closely related basic helix-loop-helix (bHLH) transcription factors that are expressed in myelinating oligodendrocytes and their progenitor cells in the developing central nervous system (CNS). Olig2 is necessary for the specification of oligodendrocytes, but the biological functions of Olig1 during oligodendrocyte lineage development are poorly understood. We show here that Olig1 function in mice is required not to develop the brain but to repair it. Specifically, we demonstrate a genetic requirement for Olig1 in repairing the types of lesions that occur in patients with multiple sclerosis.

MeSH Terms

Animals Animals, Newborn Basic Helix-Loop-Helix Transcription Factors Brain/growth & development,physiology Cell Nucleus/metabolism Cuprizone/pharmacology Cytoplasm/metabolism DNA-Binding Proteins/genetics,metabolism Demyelinating Diseases/physiopathology Ethidium/pharmacology Humans Lysophosphatidylcholines/pharmacology Mice Mice, Inbred C57BL Multiple Sclerosis/physiopathology Myelin Sheath/physiology Nerve Tissue Proteins/genetics,metabolism,physiology Oligodendrocyte Transcription Factor 2 Oligodendroglia/physiology Rats Rats, Sprague-Dawley Spinal Cord/growth & development,physiology Stem Cells/physiology Transcription Factors/genetics,metabolism

Chemicals

Basic Helix-Loop-Helix Transcription Factors DNA-Binding Proteins Lysophosphatidylcholines Nerve Tissue Proteins OLIG1 protein, human OLIG2 protein, human Olig1 protein, mouse Olig1 protein, rat Olig2 protein, mouse Oligodendrocyte Transcription Factor 2 Transcription Factors Cuprizone Ethidium

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Arnett Heather A

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

Fancy Stephen P J

Alberta John A

Zhao Chao

Plant Sheila R

Kaing Sovann

Raine Cedric S

Rowitch David H

Franklin Robin J M

Stiles Charles D

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

1095-9203

DOI

10.1126/science.1103709

Published

2004-12-17

Pages

2111-5

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

Multiple Sclerosis Society · 689 · United Kingdom

NINDS NIH HHS · NS08952 · United States

NINDS NIH HHS · NS11920 · United States

NINDS NIH HHS · NS4051 · United States

External Links

PubMed source DOI: 10.1126/science.1103709 View journal details

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bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS.

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