A survey of current software for linkage analysis.

Human genomics ·Vol. 1 ·No. 1 ·2003-11-00 ·Pages 63-5

Dudbridge F

Abstract

There is now a wide choice of software available for linkage analysis. The most well known packages are briefly reviewed here. The package with the most extensive range of analyses is GENEHUNTER, but for many of its functions there are other programs with better performance. These include FASTLINK and VITESSE for parametric analysis ALLEGRO and MERLIN for non-parametric analysis and SOLAR for variance components analysis. The computational limits of current approaches can be improved with SIMWALK2 and the promising new SUPERLINK program. Directions for future work include improved user interfaces and consensus formats for data input and exchange.

MeSH Terms

Algorithms Computer Systems Data Collection Genes, Recessive Genetic Linkage Genetic Markers Haplotypes Humans Lod Score Microsatellite Repeats Pedigree Polymorphism, Single Nucleotide Quantitative Trait, Heritable Regression Analysis Software

Chemicals

Genetic Markers

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Dudbridge Frank

MRC Human Genome Mapping Project Resource Centre, Hinxton, Cambridge CB10 1SB, UK. f.dudbridge@hgmp.mrc.ac.uk

References (18)

18 references, click to expand

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Article Info

Journal

Human genomics

Abbr.

Hum Genomics

ISSN

1473-9542

DOI

10.1186/1479-7364-1-1-63

f.dudbridge@hgmp.mrc.ac.uk

Published

2003-11-00

Pages

63-5

Language

English

Region

England

NLM ID

101202210

PMCID

PMC3525006

Subset

External Links

PubMed source DOI: 10.1186/1479-7364-1-1-63 PMC Full Text View journal details

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A survey of current software for linkage analysis.

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