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PMID: 15590929 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Boosting of action potential backpropagation by neocortical network activity in vivo.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 24 ·No. 49 ·2004-12-08 ·Pages 11127-36

Waters J, Helmchen F

Abstract

Action potentials backpropagate into the dendritic trees of pyramidal neurons, reporting output activity to the sites of synaptic input and provoking long-lasting changes in synaptic strength. It is unclear how this retrograde signal is modified by neural network activity. Using whole-cell recordings from somata, apical trunks, and dendritic tuft branches of layer 2/3 pyramidal neurons in vivo, we show that network-driven subthreshold membrane depolarizations ("up states") occur simultaneously throughout the apical dendritic tree. This spontaneous synaptic activity enhances action potential-evoked calcium influx into the distal apical dendrite by promoting action potential backpropagation. Hence, somatic feedback to the dendrites becomes stronger with increasing network activity.

MeSH Terms
Action Potentials/physiology Animals Calcium/metabolism,physiology Dendrites/physiology Electroencephalography Neocortex/physiology Nerve Net/physiology Pyramidal Cells/physiology Rats Rats, Wistar Signal Processing, Computer-Assisted Synapses/physiology
Chemicals
Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Waters Jack
Abteilung Zellphysiologie, Max-Planck-Institut für medizinische Forschung, 69120 Heidelberg, Germany. jwaters@mpimf-heidelberg.mpg.de
Helmchen Fritjof
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
DOI
10.1523/JNEUROSCI.2933-04.2004
Email
jwaters@mpimf-heidelberg.mpg.de
Published
2004-12-08
Pages
11127-36
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6730284
Subset
IM
External Links
PubMed source DOI: 10.1523/JNEUROSCI.2933-04.2004 PMC Full Text View journal details
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