The relationship between circulating concentrations of C-reactive protein, inflammatory cytokines and cytokine receptors in patients with non-small-cell lung cancer.

British journal of cancer ·Vol. 91 ·No. 12 ·2004-12-13 ·Pages 1993-5

McKeown DJ, Brown DJ, Kelly A, Wallace AM, McMillan DC

Abstract

The relationship between circulating C-reactive protein concentrations and potential cytokine and receptor mediators (interleukin-6, leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), soluble IL-6 receptor, soluble gp130, soluble TNF receptor, interleukin-1 receptor antagonist and interleukin-8 (IL-8)) of this acute phase protein were examined in healthy subjects (n=11) and patients with non-small-cell lung cancer (n=50). Leukaemia inhibitory factor and CNTF were below detection limits in all controls and patients. C-reactive protein, interleukin-6, soluble gp130, soluble TNF receptor, interleukin-1 receptor antagonist and IL-8 concentrations were significantly elevated in cancer patients (P< or =0.001). Cancer patients with elevated C-reactive protein concentrations had greater concentrations of interleukin-6 (P<0.01) and interleukin-1 receptor antagonist (P<0.05). On regression analysis only interleukin-6 was independently associated with C-reactive protein (r=0.616, P<0.001). Interleukin-6 is an important independent mediator of elevated C-reactive protein concentrations in patients with non-small-cell lung cancer.

MeSH Terms

Adult Aged Aged, 80 and over Biomarkers, Tumor/blood C-Reactive Protein/analysis Carcinoma, Non-Small-Cell Lung/blood Cytokines/blood Enzyme-Linked Immunosorbent Assay Female Humans Lung Neoplasms/blood Male Middle Aged Receptors, Cytokine/blood

Chemicals

Biomarkers, Tumor Cytokines Receptors, Cytokine C-Reactive Protein

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

McKeown D J

University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK.

Brown D J F

Kelly A

Wallace A M

McMillan D C

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Article Info

Journal

British journal of cancer

Abbr.

Br J Cancer

ISSN

0007-0920

DOI

10.1038/sj.bjc.6602248

Published

2004-12-13

Pages

1993-5

Language

English

Region

England

NLM ID

0370635

PMCID

PMC2410147

Subset

External Links

PubMed source DOI: 10.1038/sj.bjc.6602248 PMC Full Text View journal details

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The relationship between circulating concentrations of C-reactive protein, inflammatory cytokines and cytokine receptors in patients with non-small-cell lung cancer.

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