Genetic control of retrovirus susceptibility in mammalian cells.

Annual review of genetics ·Vol. 38 ·2004-00-00 ·Pages 61-85

Goff SP

Abstract

Host cellular genes can have profound effects on retrovirus replication. Many of these genes encode restriction factors that block virus infection; others encode positive factors that are exploited by the viruses. Recently, a number of such genes have been cloned and characterized, bringing into sharper focus the mechanisms and pathways exploited by these viruses. The major host factors involved in the early phase of the viral life cycle are discussed.

MeSH Terms

APOBEC-3G Deaminase Animals Antiviral Restriction Factors Carrier Proteins/genetics Cell Line Cyclophilin A/immunology Cytidine Deaminase DNA, Complementary/genetics DNA-(Apurinic or Apyrimidinic Site) Lyase/genetics Genes HIV-1/genetics,immunology Humans Macaca mulatta/genetics,immunology Mice Nucleoside Deaminases Proteins/genetics,immunology Repressor Proteins Retroviridae/genetics,physiology Retroviridae Infections/genetics Tripartite Motif Proteins Ubiquitin-Protein Ligases Virus Replication

Chemicals

Antiviral Restriction Factors Carrier Proteins DNA, Complementary Fv1 protein, mouse Proteins Repressor Proteins Tripartite Motif Proteins TRIM5 protein, human Ubiquitin-Protein Ligases Nucleoside Deaminases APOBEC-3G Deaminase APOBEC3G protein, human Cytidine Deaminase APEX1 protein, human DNA-(Apurinic or Apyrimidinic Site) Lyase Cyclophilin A

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Goff Stephen P

Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, New York, NY 10032, USA. goff@cancercenter.columbia.edu

Article Info

Journal

Annual review of genetics

Abbr.

Annu Rev Genet

ISSN

0066-4197

DOI

10.1146/annurev.genet.38.072902.094136

goff@cancercenter.columbia.edu

Published

2004-00-00

Pages

61-85

Language

English

Region

United States

NLM ID

0117605

Subset

External Links

PubMed source DOI: 10.1146/annurev.genet.38.072902.094136 View journal details

Analysis Services

Genetic control of retrovirus susceptibility in mammalian cells.

Contact

WeChat Official Account