New cholesterol biosynthesis inhibitors MC-031 (O-demethylchlorothricin), -032 (O-demethylhydroxychlorothricin), -033 and -034.

The Journal of antibiotics ·Vol. 45 ·No. 2 ·1992-02-00 ·Pages 207-12

Kawashima A, Nakamura Y, Ohta Y, Akama T, Yamagishi M, Hanada K

Abstract

In the course of our screening for microbial compounds which possessed inhibitory activities against biosynthesis of cholesterol from mevalonate, we isolated four new compounds from the cultural broth of Streptomyces sp. A7361. They are structurally related to, but distinct from chlorothricin.

MeSH Terms

Anti-Bacterial Agents/chemistry,isolation & purification,pharmacology Chemical Phenomena Chemistry, Physical Fermentation Macrolides Streptomyces/metabolism

Chemicals

Anti-Bacterial Agents Macrolides MC 033 MC 034 O-demethylhydroxychlorothricin O-demethylchlorothricin

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Kawashima A

Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.

Nakamura Y

Ohta Y

Akama T

Yamagishi M

Hanada K

Article Info

Journal

The Journal of antibiotics

Abbr.

J Antibiot (Tokyo)

ISSN

0021-8820

DOI

10.7164/antibiotics.45.207

Published

1992-02-00

Pages

207-12

Language

English

Region

Japan

NLM ID

0151115

Subset

External Links

PubMed source DOI: 10.7164/antibiotics.45.207 View journal details

Analysis Services

New cholesterol biosynthesis inhibitors MC-031 (O-demethylchlorothricin), -032 (O-demethylhydroxychlorothricin), -033 and -034.

Contact

WeChat Official Account