The role of interferon gamma in the pathogenesis of Crohn's disease.

Gastroenterologia Japonica ·Vol. 27 ·No. 1 ·1992-02-00 ·Pages 29-36

Sasaki T, Hiwatashi N, Yamazaki H, Noguchi M, Toyota T

Abstract

To investigate the role of interferon gamma in the pathogenesis of Crohn's disease, we examined the interferon gamma levels of serum, supernatant of cultured peripheral blood mononuclear cells activated by phytohemagglutinin, and medium of organ culture of colonic mucosa in Crohn's disease. Serum interferon gamma levels in Crohn's disease, especially in active or non-resected Crohn's disease, were more elevated than those in normal subjects. In contrast, the production of interferon gamma by peripheral blood mononuclear cells was reduced in Crohn's disease. In some patients, interferon gamma levels of organ culture medium of colonic mucosal tissue specimens were elevated. When peripheral blood mononuclear cells were preincubated for 72 hours, interferon gamma production in Crohn's disease increased from 23.8% to 62.3% in comparison to levels in healthy controls. These results indicate that elevated serum interferon gamma in Crohn's disease may originate from the intestine, and interferon gamma may be related to the immune reaction and inflammation in the intestine.

MeSH Terms

Adult Colitis, Ulcerative/metabolism Colon/metabolism Crohn Disease/etiology,metabolism Female Humans Interferon-gamma/analysis,physiology Intestinal Mucosa/metabolism Leukocytes, Mononuclear/metabolism Male

Chemicals

Interferon-gamma

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Sasaki T

Third Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.

Hiwatashi N

Yamazaki H

Noguchi M

Toyota T

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Article Info

Journal

Gastroenterologia Japonica

Abbr.

Gastroenterol Jpn

ISSN

0435-1339

Published

1992-02-00

Pages

29-36

Language

English

Region

Japan

NLM ID

0152744

Subset

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The role of interferon gamma in the pathogenesis of Crohn's disease.

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