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题目:: Association of CyclinD1 copy number changes with histological type in ovarian tumors.
作者:: Dimova(Ivanka),Zaharieva(Boriana),Raicheva(Sashka),Milev(Ivan),Dimitrov(Rumen),Doganov(Nicolai),Aleksandrov(Marin),Todorov(Todor),Toncheva(Draga)
状态:: 发布时间2004-11-16 , 更新时间 2009-05-12
期刊:: Acta Oncol
摘要:: Literature data on the occurrence of CCND1 alterations in ovarian tumors are insufficient. The objective of this study was to assess the incidence of CCND1 copy number changes in a large number of ovarian tumors and its relation to the tumor phenotype: degree of malignancy, histological type, tumor stage, and grade. Fluorescence in situ hybridization (FISH) for analysis of CCND1 copy number changes was applied on a collection of 1 006 ovarian tumors--468 malignant, 48 with low malignant potency, and 490 benign tumors--arranged in tissue microarray. CCND1 amplification was found in 8.46% of the malignant cases and in 8.11% of those with low malignant potency. It was not found in benign ovarian tumors. CCND1 amplification was associated with the mucinous type of ovarian cancer (p<0.0001). CCND1 genetic gain was revealed in 9.06% of the malignant tumors, in 2.70% of the tumors with low malignant potency, and in 4.87% of the benign ovarian tumors. CCND1 gains and amplifications were not associated with the tumor grade and stage. Our results suggest that CCND1 gains are early events in ovarian tumorogenesis.
语言:: eng
DOI:: 10.1080/02841860410018548

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