Home LiteratureArticle Details

PMID: 15539639 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

The mitochondrial death pathway and cardiac myocyte apoptosis.

Circulation research ·Vol. 95 ·No. 10 ·2004-11-12 ·Pages 957-70

Crow MT, Mani K, Nam YJ, Kitsis RN

Abstract

Apoptosis has been causally linked to the pathogenesis of myocardial infarction and heart failure in rodent models. This death process is mediated by two central pathways, an extrinsic pathway involving cell surface receptors and an intrinsic pathway using mitochondria and the endoplasmic reticulum. Each of these pathways has been implicated in myocardial pathology. In this review, we summarize recent advances in the understanding of the intrinsic pathway and how it relates to cardiac myocyte death and heart disease.

MeSH Terms

Animals Apoptosis/physiology Apoptosis Inducing Factor Caspases/physiology Cytochromes c/metabolism Endoplasmic Reticulum/physiology Enzyme Activation Flavoproteins/pharmacology Gene Expression Regulation Heart Diseases/pathology Humans Ion Channels/physiology Membrane Proteins/pharmacology Mitochondria, Heart/physiology Mitochondrial Membrane Transport Proteins Mitochondrial Permeability Transition Pore Myocytes, Cardiac/cytology Protein Structure, Tertiary Proto-Oncogene Proteins/chemistry,physiology Rodentia Stress, Physiological/pathology Tumor Suppressor Protein p53/physiology

Chemicals

AIFM1 protein, human Apoptosis Inducing Factor Flavoproteins Ion Channels Membrane Proteins Mitochondrial Membrane Transport Proteins Mitochondrial Permeability Transition Pore Proto-Oncogene Proteins Tumor Suppressor Protein p53 Cytochromes c Caspases

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Crow Michael T

Department of Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Rm 5A.58, Baltimore, MD 21224, USA. mcrow1@jhmi.edu

Mani Kartik

Nam Young-Jae

Kitsis Richard N

Article Info

Journal

Circulation research

Abbr.

Circ Res

ISSN

1524-4571

DOI

10.1161/01.RES.0000148632.35500.d9

mcrow1@jhmi.edu

Published

2004-11-12

Pages

957-70

Language

English

Region

United States

NLM ID

0047103

Subset

Grants

NHLBI NIH HHS · HL60665 · United States

NHLBI NIH HHS · HL61550 · United States

NHLBI NIH HHS · R01S HL73935 · United States

NIGMS NIH HHS · T32 GM07491 · United States

External Links

PubMed source DOI: 10.1161/01.RES.0000148632.35500.d9 View journal details

Analysis Services

The mitochondrial death pathway and cardiac myocyte apoptosis.

Contact

WeChat Official Account