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PMID: 15501801 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Mucosal administration of flagellin induces innate immunity in the mouse lung.

Infection and immunity ·Vol. 72 ·No. 11 ·2004-11-00 ·Pages 6676-9

Honko AN, Mizel SB

Abstract

Nonsurgical intratracheal instillation of 1 microg of purified, recombinant flagellin in several strains of mice stimulated a transient innate immune response in the lung characterized by the infiltration of neutrophils and the rapid production of tumor necrosis factor alpha, interleukin 6, granulocyte colony-stimulating factor, and the chemokines keratinocyte-derived chemokine, MIP1alpha, and MIP-2.

MeSH Terms
Animals Chemokine CCL4 Chemokine CXCL2 Cytokines/metabolism Female Flagellin/administration & dosage,genetics,immunology Gram-Negative Bacteria/immunology Granulocyte Colony-Stimulating Factor/metabolism Immunity, Innate Interleukin-6/metabolism Lung/immunology Macrophage Inflammatory Proteins/metabolism Mice Mice, Inbred BALB C Mice, Inbred C3H Monokines/metabolism Neutrophils/immunology Recombinant Proteins/administration & dosage,immunology Salmonella enteritidis/immunology Tumor Necrosis Factor-alpha/metabolism
Chemicals
Chemokine CCL4 Chemokine CXCL2 Cytokines Interleukin-6 Macrophage Inflammatory Proteins Monokines Recombinant Proteins Tumor Necrosis Factor-alpha Flagellin Granulocyte Colony-Stimulating Factor
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Honko Anna N
Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.
Mizel Steven B
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.72.11.6676-6679.2004
Published
2004-11-00
Pages
6676-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC523048
Subset
IM
Grants
NIAID NIH HHS · R01 AI051319 · United States
NIAID NIH HHS · T32 AI007401 · United States
NIAID NIH HHS · R01-AI51319 · United States
NIAID NIH HHS · T32-AI007401 · United States
External Links
PubMed source DOI: 10.1128/IAI.72.11.6676-6679.2004 PMC Full Text View journal details
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