Home LiteratureArticle Details

PMID: 15499008 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Systems biology and new technologies enable predictive and preventative medicine.

Science (New York, N.Y.) ·Vol. 306 ·No. 5696 ·2004-10-22 ·Pages 640-3

Hood L, Heath JR, Phelps ME, Lin B

Abstract

Systems approaches to disease are grounded in the idea that disease-perturbed protein and gene regulatory networks differ from their normal counterparts; we have been pursuing the possibility that these differences may be reflected by multiparameter measurements of the blood. Such concepts are transforming current diagnostic and therapeutic approaches to medicine and, together with new technologies, will enable a predictive and preventive medicine that will lead to personalized medicine.

MeSH Terms

Biomarkers/blood Computational Biology Databases, Nucleic Acid Diagnosis Disease Disease Progression Forecasting Gene Expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Male Microfluidics Nanotechnology Preventive Medicine Prostate/physiology Prostatic Neoplasms/genetics,metabolism Systems Analysis Systems Theory Therapeutics

Chemicals

Biomarkers

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Hood Leroy

Institute for Systems Biology, Seattle, WA, USA. lhood@systemsbiology.org

Heath James R

Phelps Michael E

Lin Biaoyang

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

1095-9203

DOI

10.1126/science.1104635

lhood@systemsbiology.org

Published

2004-10-22

Pages

640-3

Language

English

Region

United States

NLM ID

0404511

Subset

Corrections

CommentIn

PMID: 19023053

External Links

PubMed source DOI: 10.1126/science.1104635 View journal details

Analysis Services

Systems biology and new technologies enable predictive and preventative medicine.

Contact

WeChat Official Account