Class switching and Myc translocation: how does DNA break?

Nature immunology ·Vol. 5 ·No. 11 ·2004-11-00 ·Pages 1101-3

Casali P, Zan H

Abstract

暂无摘要

MeSH Terms

Animals Antibodies/genetics Cytidine Deaminase Cytosine Deaminase/metabolism DNA Glycosylases/genetics,metabolism Genes, myc Humans Immunoglobulin Class Switching/genetics,physiology Mutation Receptors, Antigen, B-Cell/genetics Translocation, Genetic/physiology Uracil-DNA Glycosidase

Chemicals

Antibodies Receptors, Antigen, B-Cell DNA Glycosylases Uracil-DNA Glycosidase AICDA (activation-induced cytidine deaminase) Cytosine Deaminase Cytidine Deaminase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Casali Paolo

Zan Hong

References (12)

12 references, click to expand

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.
Nat Cell Biol. 2003 Jul;5(7):675-9 PMID: 12792649
Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice.
Curr Biol. 2002 Oct 15;12(20):1748-55 PMID: 12401169
Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination.
Nat Immunol. 2003 Oct;4(10):1023-8 PMID: 12958596
Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch.
Science. 2004 Aug 20;305(5687):1160-3 PMID: 15326357
The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process.
J Exp Med. 2002 May 6;195(9):1193-8 PMID: 11994424
DNA double-strand breaks: prior to but not sufficient in targeting hypermutation.
J Exp Med. 2002 May 6;195(9):1187-92 PMID: 11994423
AID-dependent generation of resected double-strand DNA breaks and recruitment of Rad52/Rad51 in somatic hypermutation.
Immunity. 2003 Jun;18(6):727-38 PMID: 12818155
Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc.
Nat Immunol. 2004 Nov;5(11):1117-23 PMID: 15489857
The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks.
J Exp Med. 2002 May 6;195(9):F37-41 PMID: 11994429
Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks.
J Biol Chem. 2004 Jun 18;279(25):26395-401 PMID: 15087440
AID is required for c-myc/IgH chromosome translocations in vivo.
Cell. 2004 Aug 20;118(4):431-8 PMID: 15315756
De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination.
Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13003-7 PMID: 15317942

Article Info

Journal

Nature immunology

Abbr.

Nat Immunol

ISSN

1529-2908

DOI

10.1038/ni1104-1101

Published

2004-11-00

Pages

1101-3

Language

English

Region

United States

NLM ID

100941354

PMCID

PMC4625794

Subset

Grants

NIAID NIH HHS · R01 AI045011 · United States

NIAMS NIH HHS · R01 AR040908 · United States

NIAID NIH HHS · R56 AI045011 · United States

Corrections

CommentOn

PMID: 15489857

External Links

PubMed source DOI: 10.1038/ni1104-1101 PMC Full Text View journal details

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Class switching and Myc translocation: how does DNA break?

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