Pharmacokinetics and pharmacodynamics of levodopa.

Neurology ·Vol. 42 ·No. 1 Suppl 1 ·1992-01-00 ·Pages 17-22; discussion 57-60

Montgomery EB

Abstract

Levodopa is effective in relieving symptoms of Parkinson's disease. However, long-term complications make sustained control problematic. Most management problems are related to the pharmacokinetic and pharmacodynamic properties of levodopa. Careful titration based on pharmacologic principles may achieve optimal therapeutic effects.

MeSH Terms

Administration, Oral Aromatic-L-Amino-Acid Decarboxylases/metabolism Blood/metabolism Brain/metabolism Digestive System/metabolism Dopamine/metabolism Dyskinesia, Drug-Induced/classification Humans Levodopa/adverse effects,pharmacokinetics,pharmacology Receptors, Dopamine/metabolism

Chemicals

Receptors, Dopamine Levodopa Aromatic-L-Amino-Acid Decarboxylases Dopamine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Montgomery E B

Department of Neurology, University of Arizona College of Medicine, Arizona Health Sciences Center, Tucson 85724.

Article Info

Journal

Neurology

Abbr.

Neurology

ISSN

0028-3878

Published

1992-01-00

Pages

17-22; discussion 57-60

Language

English

Region

United States

NLM ID

0401060

Subset

External Links

PubMed source View journal details

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Pharmacokinetics and pharmacodynamics of levodopa.

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