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PMID: 15457249 Published · ppublish English Journal Article

Lung cancer: intragenic ERBB2 kinase mutations in tumours.

Nature ·Vol. 431 ·No. 7008 ·2004-09-30 ·Pages 525-6

Stephens P, Hunter C, Bignell G, Edkins S, Davies H, Teague J, Stevens C, O'Meara S, Smith R, Parker A, Barthorpe A, Blow M, Brackenbury L, Butler A, Clarke O, Cole J, Dicks E, Dike A, Drozd A, Edwards K, Forbes S, Foster R, Gray K, Greenman C, Halliday K, Hills K, Kosmidou V, Lugg R, Menzies A, Perry J, Petty R, Raine K, Ratford L, Shepherd R, Small A, Stephens Y, Tofts C, Varian J, West S, Widaa S, Yates A, Brasseur F, Cooper CS, Flanagan AM, Knowles M, Leung SY, Louis DN, Looijenga LH, Malkowicz B, Pierotti MA, Teh B, Chenevix-Trench G, Weber BL, Yuen ST, Harris G, Goldstraw P, Nicholson AG, Futreal PA, Wooster R, Stratton MR

Abstract

The protein-kinase family is the most frequently mutated gene family found in human cancer and faulty kinase enzymes are being investigated as promising targets for the design of antitumour therapies. We have sequenced the gene encoding the transmembrane protein tyrosine kinase ERBB2 (also known as HER2 or Neu) from 120 primary lung tumours and identified 4% that have mutations within the kinase domain; in the adenocarcinoma subtype of lung cancer, 10% of cases had mutations. ERBB2 inhibitors, which have so far proved to be ineffective in treating lung cancer, should now be clinically re-evaluated in the specific subset of patients with lung cancer whose tumours carry ERBB2 mutations.

MeSH Terms
Carcinoma, Non-Small-Cell Lung/drug therapy,genetics DNA Mutational Analysis Enzyme Activation ErbB Receptors/chemistry,genetics Gefitinib Humans Lung Neoplasms/drug therapy,genetics Models, Molecular Mutation/genetics Neoplasms/drug therapy,genetics Protein Structure, Tertiary Quinazolines/therapeutic use Receptor, ErbB-2/chemistry,genetics,metabolism
Chemicals
Quinazolines ErbB Receptors Receptor, ErbB-2 Gefitinib
Authors & Affiliations
60 authors, click to expand affiliations / ORCID
Stephens Philip
Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.
Hunter Chris
Bignell Graham
Edkins Sarah
Davies Helen
Teague Jon
Stevens Claire
O'Meara Sarah
Smith Raffaella
Parker Adrian
Barthorpe Andy
Blow Matthew
Brackenbury Lisa
Butler Adam
Clarke Oliver
Cole Jennifer
Dicks Ed
Dike Angus
Drozd Anja
Edwards Ken
Forbes Simon
Foster Rebecca
Gray Kristian
Greenman Chris
Halliday Kelly
Hills Katy
Kosmidou Vivienne
Lugg Richard
Menzies Andy
Perry Janet
Petty Robert
Raine Keiran
Ratford Lewis
Shepherd Rebecca
Small Alexandra
Stephens Yvonne
Tofts Calli
Varian Jennifer
West Sofie
Widaa Sara
Yates Andrew
Brasseur Francis
Cooper Colin S
Flanagan Adrienne M
Knowles Margaret
Leung Suet Y
Louis David N
Looijenga Leendert H J
Malkowicz Bruce
Pierotti Marco A
Teh Bin
Chenevix-Trench Georgia
Weber Barbara L
Yuen Siu T
Harris Grace
Goldstraw Peter
Nicholson Andrew G
Futreal P Andrew
Wooster Richard
Stratton Michael R
Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
Published
2004-09-30
Pages
525-6
Language
English
Region
England
NLM ID
0410462
Subset
IM
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