The activation effect of calcium on a bactericidal substance for Bacillus subtilis in human serum.
An enhanced bactericidal activity of human serum for B. subtilis develops during many different forms of illness, e.g. carcinoma, virus and bacterial infections, and during acute coronary occlusion. This increased bactericidal effect cannot be related to leucocytosis, fever, serum complement, C-reactive protein, or a specific antibody reaction. The serum bactericidal factor becomes inactive in decalcified serum, but active again when optimal concentrations of calcium are added. Magnesium does not cause reactivation.
4 references, click to expand
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THE BACTERICIDAL ACTION OF HUMAN SERUM ON HEMOLYTIC STREPTOCOCCI : III. STUDIES CONCERNING: (1) THE SIGNIFICANCE OF HYDROGEN ION CONCENTRATION IN RELATION TO THE STREPTOCOCCIDAL ACTION OF SERUM; (2) THE EFFECT OF REDUCING AGENTS ON THE PHENOMENON.J Exp Med. 1937 Oct 31;66(5):617-36 PMID: 19870687
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