JNKing Revealed.

Molecular cell ·Vol. 15 ·No. 6 ·2004-09-24 ·Pages 843-4

Ronai Z

Abstract

In a recent issue of Molecular Cell, Sabapathy et al. (2004) demonstrate that JNK2 destabilizes c-Jun under nonstimulating conditions, whereas after stress, activated JNK1 phosphorylates c-Jun, resulting in its activation and stabilization, thereby highlighting functional differences between JNK1 and JNK2.

MeSH Terms

Animals Cells, Cultured Enzyme Activation Fibroblasts/metabolism Mice Mice, Knockout Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinase 9 Mitogen-Activated Protein Kinases/metabolism Models, Biological Phosphorylation Proto-Oncogene Proteins c-jun/metabolism Substrate Specificity

Chemicals

Proto-Oncogene Proteins c-jun Mitogen-Activated Protein Kinase 9 Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinases

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Ronai Ze'ev

Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA.

Article Info

Journal

Molecular cell

Abbr.

Mol Cell

ISSN

1097-2765

DOI

10.1016/j.molcel.2004.09.011

Published

2004-09-24

Pages

843-4

Language

English

Region

United States

NLM ID

9802571

Subset

Corrections

CommentOn

PMID: 15350216

External Links

PubMed source DOI: 10.1016/j.molcel.2004.09.011 View journal details

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