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PMID: 15371360 Published · ppublish English Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S.

Mapping quantitative trait loci for anxiety in chromosome substitution strains of mice.

Genetics ·Vol. 169 ·No. 2 ·2005-02-00 ·Pages 855-62

Singer JB, Hill AE, Nadeau JH, Lander ES

Abstract

Anxious behavior in the mouse is a complex quantitative phenotype that varies widely among inbred mouse strains. We examined a panel of chromosome substitution strains bearing individual A/J chromosomes in an otherwise C57BL/6J background in open-field and light-dark transition tests. Our results confirmed previous reports of quantitative trait loci (QTL) on chromosomes 1, 4, and 15 and identified novel loci on chromosomes 6 and 17. The studies were replicated in two separate laboratories. Systematic differences in the overall activity level were found between the two facilities, but the presence of the QTL was confirmed in both laboratories. We also identified specific effects on open-field defecation and center avoidance and distinguished them from overall open-field activity.

MeSH Terms
Animals Anxiety/genetics Chromosome Mapping/methods Chromosomes Exploratory Behavior Male Mice Mice, Inbred A Mice, Inbred C57BL Quantitative Trait Loci
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Singer Jonathan B
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA. jonathan.singer@pharma.novartis.com
Hill Annie E
Nadeau Joseph H
Lander Eric S
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1534/genetics.104.031492
Email
jonathan.singer@pharma.novartis.com
Published
2005-02-00
Epub
2004-00-15
Pages
855-62
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1449086
Subset
IM
Grants
NICHD NIH HHS · HD07518 · United States
NIGMS NIH HHS · GM07250 · United States
NCRR NIH HHS · P40 RR012305 · United States
NCRR NIH HHS · RR12305 · United States
NICHD NIH HHS · T32 HD007518 · United States
NIGMS NIH HHS · T32 GM007250 · United States
External Links
PubMed source DOI: 10.1534/genetics.104.031492 PMC Full Text View journal details
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