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PMID: 15371336 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Essential and separable roles for Syndecan-3 and Syndecan-4 in skeletal muscle development and regeneration.

Genes & development ·Vol. 18 ·No. 18 ·2004-09-15 ·Pages 2231-6

Cornelison DD, Wilcox-Adelman SA, Goetinck PF, Rauvala H, Rapraeger AC, Olwin BB

Abstract

Syndecan-3 and syndecan-4 function as coreceptors for tyrosine kinases and in cell adhesion. Syndecan-3(-/-) mice exhibit a novel form of muscular dystrophy characterized by impaired locomotion, fibrosis, and hyperplasia of myonuclei and satellite cells. Explanted syndecan-3(-/-) satellite cells mislocalize MyoD, differentiate aberrantly, and exhibit a general increase in overall tyrosine phosphorylation. Following induced regeneration, the hyperplastic phenotype is recapitulated. While there are fewer apparent defects in syndecan-4(-/-) muscle, explanted satellite cells are deficient in activation, proliferation, MyoD expression, myotube fusion, and differentiation. Further, syndecan-4(-/-) satellite cells fail to reconstitute damaged muscle, suggesting a unique requirement for syndecan-4 in satellite cell function.

MeSH Terms
Animals Cell Division/genetics Cells, Cultured Female Gene Expression Regulation, Developmental Membrane Glycoproteins/genetics,physiology Mice Mice, Mutant Strains Muscle Development/physiology Muscle Fibers, Skeletal/pathology,physiology Muscle, Skeletal/growth & development,physiology Muscular Dystrophies/genetics,physiopathology MyoD Protein/metabolism Proteoglycans/genetics,physiology Regeneration/genetics Satellite Cells, Skeletal Muscle/pathology Syndecan-3 Syndecan-4
Chemicals
Membrane Glycoproteins MyoD Protein Proteoglycans Sdc3 protein, mouse Sdc4 protein, mouse Syndecan-3 Syndecan-4
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Cornelison D D W
Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado 80309, USA.
Wilcox-Adelman Sarah A
Goetinck Paul F
Rauvala Heikki
Rapraeger Alan C
Olwin Bradley B
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Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
0890-9369
DOI
10.1101/gad.1214204
Published
2004-09-15
Pages
2231-6
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC517515
Subset
IM
Grants
NIAMS NIH HHS · AR39467 · United States
NIGMS NIH HHS · GM48850 · United States
NIGMS NIH HHS · R01 GM048850 · United States
NICHD NIH HHS · HD21881 · United States
NICHD NIH HHS · R01 HD037490 · United States
NIAMS NIH HHS · R01 AR039467 · United States
NICHD NIH HHS · HD37490 · United States
External Links
PubMed source DOI: 10.1101/gad.1214204 PMC Full Text View journal details
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