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题目:: Inhibitory effect of IL-6-induced neuroendocrine cells on prostate cancer cell proliferation.
作者:: Wang(Qingcai),Horiatis(Dimitris),Pinski(Jacek)
状态:: 发布时间2004-09-20 , 更新时间 2004-11-17
期刊:: Prostate
摘要:: The role of increased neuroendocrine (NE) differentiation in prostate cancer (PCA) is not well understood. Long-term exposure of the prostate cancer cell line LNCaP to high concentrations of the cytokine interleukin-6 (IL-6) results in permanent transdifferentiation of these cells into a NE phenotype. In this study, we evaluated the effect of IL-6-induced NE cells on the growth of the PCA cell lines LNCaP, PC-3, and DU-145 in vitro.,Co-culture of NE cells with PCA cells significantly inhibited DNA synthesis in all three PCA cell lines by 30-90% compared to controls. NE cell co-culture resulted in an increased percentage of PCA cells arrested in the S-phase of cell cycle and PCA cell apoptosis.,Our results imply that NE cells suppress the proliferation of surrounding PCA cells by release of inhibitory factors.
语言:: eng
DOI:: 10.1002/pros.20106

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