Medicine. Targeting apoptotic pathways in cancer cells.

Alkynes/chemical synthesis,chemistry,metabolism,pharmacology Amino Acid Substitution Animals Apoptosis Apoptosis Regulatory Proteins Bridged-Ring Compounds/chemical synthesis,chemistry,metabolism,pharmacology Carrier Proteins/metabolism Cell Membrane/metabolism Diynes Endocytosis Glioblastoma/drug therapy Humans Inhibitor of Apoptosis Proteins Intracellular Signaling Peptides and Proteins Leukemia, Experimental/drug therapy Leukemic Infiltration/drug therapy Ligands Mice Mitochondria/metabolism Mitochondrial Proteins/metabolism Molecular Mimicry Peptide Fragments/chemistry Peptide Library Peptides/chemical synthesis,chemistry,metabolism,pharmacology Protein Binding Protein Engineering Protein Interaction Mapping Protein Structure, Secondary Proteins/antagonists & inhibitors,chemistry,metabolism Proto-Oncogene Proteins/chemistry Tetrazoles/chemical synthesis,chemistry,metabolism,pharmacology Tumor Necrosis Factor-alpha/pharmacology

1,6-bis(4,7-diaza-6-methyl-5-oxo-3-((2-((5-(phenylthio)tetrazol-1-yl)methyl)pyrrolidin-1-yl)carbonyl)octyloxy)-2,4-hexadiyne Alkynes Apoptosis Regulatory Proteins Bax protein (53-86) Bridged-Ring Compounds Carrier Proteins DIABLO protein, human Diablo protein, mouse Diynes Inhibitor of Apoptosis Proteins Intracellular Signaling Peptides and Proteins Ligands Mitochondrial Proteins Peptide Fragments Peptide Library Peptides Proteins Proto-Oncogene Proteins Tetrazoles Tumor Necrosis Factor-alpha