Imiquimod 5 percent cream and the treatment of cutaneous malignancy.

Dermatology online journal ·Vol. 10 ·No. 1 ·2004-07-15 ·Pages 4

Navi D, Huntley A

Abstract

Imiquimod is a novel synthetic compound that is a member of the imidazoquinolone family of drugs. This class of drugs, which also includes a more potent member, resimiquimod (R-848), is unique having the properties of topical immune response modifiers and stimulators. Imiquimod resembles a nucleoside analogue and is known for its potent induction of endogenous antiviral pro-inflammatory mediators. This article is a review of the relevant literature as it relates to the off-label applications of imiquimod 5 percent cream for treatment of cutaneous preneoplastic and neoplastic conditions including its recently approved indication for treating actinic keratoses.

MeSH Terms

Aminoquinolines/administration & dosage,adverse effects,pharmacology,therapeutic use Antineoplastic Agents/administration & dosage,adverse effects,pharmacology,therapeutic use Apoptosis/drug effects Bowen's Disease/drug therapy Carcinoma, Basal Cell/drug therapy Carcinoma, Squamous Cell/drug therapy Cell Line, Tumor/drug effects Clinical Trials as Topic Condylomata Acuminata/drug therapy Drug Screening Assays, Antitumor Female Humans Hutchinson's Melanotic Freckle/drug therapy Imiquimod Immunity, Cellular/drug effects Immunologic Factors/administration & dosage,adverse effects,pharmacology,therapeutic use Keratoacanthoma/drug therapy Keratosis/drug therapy Male Melanoma/drug therapy,secondary Multicenter Studies as Topic Mycosis Fungoides/drug therapy Ointments Paget Disease, Extramammary/drug therapy Precancerous Conditions/drug therapy Randomized Controlled Trials as Topic Skin Neoplasms/drug therapy

Chemicals

Aminoquinolines Antineoplastic Agents Immunologic Factors Ointments Imiquimod

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Navi Daniel

School of Medicine, University of California Davis, USA.

Huntley Arthur

Article Info

Journal

Dermatology online journal

Abbr.

Dermatol Online J

ISSN

1087-2108

Published

2004-07-15

Epub

2004-00-15

Pages

Language

English

Region

United States

NLM ID

9610776

Subset

External Links

PubMed source

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Imiquimod 5 percent cream and the treatment of cutaneous malignancy.

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