Home LiteratureArticle Details
PMID: 15342545 Published · ppublish English Journal Article

Genes encoding subunits of stable complexes are clustered on the yeast chromosomes: an interpretation from a dosage balance perspective.

Genetics ·Vol. 167 ·No. 4 ·2004-08-00 ·Pages 2121-5

Teichmann SA, Veitia RA

Abstract

Genomic evidence for colocalization of functionally related genes on eukaryote chromosomes is mounting. Here we show that a statistically significant fraction of yeast genes coding for subunits of stable complexes are located within 10-30 kb of each other. Clustering of genes encoding subunits of complexes may ensure better coregulation and maintain the right stoichiometry of complexes upon duplication of chromosomal segments.

MeSH Terms
Chromosomes, Fungal/genetics Gene Dosage Genes, Fungal Multigene Family Protein Subunits/genetics Saccharomyces cerevisiae/genetics Saccharomyces cerevisiae Proteins/genetics
Chemicals
Protein Subunits Saccharomyces cerevisiae Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Teichmann Sarah Amalia
MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, England.
Veitia Reiner Albert
References (13)
13 references, click to expand
  1. A computational analysis of whole-genome expression data reveals chromosomal domains of gene expression.
    Nat Genet. 2000 Oct;26(2):183-6 PMID: 11017073
  2. Prevalence of small inversions in yeast gene order evolution.
    Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14433-7 PMID: 11087826
  3. Dosage-dependent gene regulation in multicellular eukaryotes: implications for dosage compensation, aneuploid syndromes, and quantitative traits.
    Dev Biol. 2001 Jun 15;234(2):275-88 PMID: 11396999
  4. Correlation between transcriptome and interactome mapping data from Saccharomyces cerevisiae.
    Nat Genet. 2001 Dec;29(4):482-6 PMID: 11694880
  5. MIPS: a database for genomes and protein sequences.
    Nucleic Acids Res. 2002 Jan 1;30(1):31-4 PMID: 11752246
  6. Relating whole-genome expression data with protein-protein interactions.
    Genome Res. 2002 Jan;12(1):37-46 PMID: 11779829
  7. Exploring the etiology of haploinsufficiency.
    Bioessays. 2002 Feb;24(2):175-84 PMID: 11835282
  8. The constraints protein-protein interactions place on sequence divergence.
    J Mol Biol. 2002 Nov 29;324(3):399-407 PMID: 12445777
  9. Yeast genome duplication was followed by asynchronous differentiation of duplicated genes.
    Nature. 2003 Feb 20;421(6925):848-52 PMID: 12594514
  10. Evidence for co-evolution of gene order and recombination rate.
    Nat Genet. 2003 Mar;33(3):392-5 PMID: 12577060
  11. Genomic gene clustering analysis of pathways in eukaryotes.
    Genome Res. 2003 May;13(5):875-82 PMID: 12695325
  12. Dosage sensitivity and the evolution of gene families in yeast.
    Nature. 2003 Jul 10;424(6945):194-7 PMID: 12853957
  13. Gene structure and organization in Caenorhabditis elegans.
    Curr Opin Genet Dev. 1996 Dec;6(6):692-8 PMID: 8994838
Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1534/genetics.103.024505
Published
2004-08-00
Pages
2121-5
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1471008
Subset
IM
External Links
PubMed source DOI: 10.1534/genetics.103.024505 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2