Home LiteratureArticle Details
PMID: 15342486 Published · ppublish English Journal Article Review

Two heads are better than one: regulation of DNA replication by hexameric helicases.

Genes & development ·Vol. 18 ·No. 17 ·2004-09-01 ·Pages 2039-45

Sclafani RA, Fletcher RJ, Chen XS

Abstract

暂无摘要

MeSH Terms
DNA/genetics,metabolism DNA Helicases/chemistry,metabolism DNA Replication/genetics,physiology Models, Genetic Replication Origin/physiology
Chemicals
DNA DNA Helicases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Sclafani Robert A
Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.
Fletcher Ryan J
Chen Xiaojiang S
References (58)
58 references, click to expand
  1. MCM proteins: DNA damage, mutagenesis and repair.
    Curr Opin Genet Dev. 2004 Feb;14(1):17-21 PMID: 15108800
  2. Two regions of simian virus 40 T antigen determine cooperativity of double-hexamer assembly on the viral origin of DNA replication and promote hexamer interactions during bidirectional origin DNA unwinding.
    J Virol. 1999 Mar;73(3):2201-11 PMID: 9971803
  3. Insights into the oligomeric states, conformational changes, and helicase activities of SV40 large tumor antigen.
    J Biol Chem. 2004 Sep 10;279(37):38952-9 PMID: 15247252
  4. Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigen.
    Cell. 2004 Oct 1;119(1):47-60 PMID: 15454080
  5. Expression of simian virus 40 T antigen in Escherichia coli: localization of T-antigen origin DNA-binding domain to within 129 amino acids.
    J Virol. 1988 Jun;62(6):1999-2006 PMID: 2835505
  6. ATP-dependent assembly of double hexamers of SV40 T antigen at the viral origin of DNA replication.
    Nature. 1989 Apr 20;338(6217):658-62 PMID: 2539565
  7. Ordered assembly of nucleoprotein structures at the bacteriophage lambda replication origin during the initiation of DNA replication.
    J Biol Chem. 1989 Jun 25;264(18):10699-708 PMID: 2525129
  8. Heat shock protein-mediated disassembly of nucleoprotein structures is required for the initiation of bacteriophage lambda DNA replication.
    J Biol Chem. 1989 Jun 25;264(18):10709-18 PMID: 2543679
  9. Binding and unwinding--how T antigen engages the SV40 origin of DNA replication.
    Cell. 1990 Jan 26;60(2):181-4 PMID: 2153460
  10. Host virus interactions in the initiation of bacteriophage lambda DNA replication. Recruitment of Escherichia coli DnaB helicase by lambda P replication protein.
    J Biol Chem. 1990 Aug 5;265(22):13297-307 PMID: 2165499
  11. Targeting the E1 replication protein to the papillomavirus origin of replication by complex formation with the E2 transactivator.
    Science. 1990 Dec 21;250(4988):1694-9 PMID: 2176744
  12. Differential induction of structural changes in the simian virus 40 origin of replication by T antigen.
    J Virol. 1991 Mar;65(3):1228-35 PMID: 1847451
  13. Simian virus 40 T-antigen DNA helicase is a hexamer which forms a binary complex during bidirectional unwinding from the viral origin of DNA replication.
    J Virol. 1992 Feb;66(2):804-15 PMID: 1309914
  14. The simian virus 40 T antigen double hexamer assembles around the DNA at the replication origin.
    J Biol Chem. 1992 Jul 15;267(20):14129-37 PMID: 1321135
  15. Initiation of chromosomal DNA replication in eukaryotes. Lessons from lambda.
    J Biol Chem. 1994 Mar 11;269(10):7047-50 PMID: 8125908
  16. Co-operative interaction between the initiator E1 and the transcriptional activator E2 is required for replicator specific DNA replication of bovine papillomavirus in vivo and in vitro.
    EMBO J. 1995 Dec 15;14(24):6218-28 PMID: 8557041
  17. Binding of the E1 and E2 proteins to the origin of replication of bovine papillomavirus.
    J Virol. 1997 Apr;71(4):2887-96 PMID: 9060646
  18. A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.
    J Biol Chem. 1997 Sep 26;272(39):24508-13 PMID: 9305914
  19. The N-terminal side of the origin-binding domain of simian virus 40 large T antigen is involved in A/T untwisting.
    J Virol. 1997 Nov;71(11):8743-9 PMID: 9343233
  20. Dimerization of simian virus 40 T-antigen hexamers activates T-antigen DNA helicase activity.
    J Virol. 1997 Nov;71(11):8766-73 PMID: 9343236
  21. A globular complex formation by Nda1 and the other five members of the MCM protein family in fission yeast.
    Genes Cells. 1997 Jul;2(7):467-79 PMID: 9366552
  22. Characterization of the DNA-binding domain of the bovine papillomavirus replication initiator E1.
    J Virol. 1998 Apr;72(4):2567-76 PMID: 9525573
  23. The DNA replication fork in eukaryotic cells.
    Annu Rev Biochem. 1998;67:721-51 PMID: 9759502
  24. Synthetic DNA replication bubbles bound and unwound with twofold symmetry by a simian virus 40 T-antigen double hexamer.
    J Virol. 1998 Nov;72(11):8676-81 PMID: 9765408
  25. Recruitment and loading of the E1 initiator protein: an ATP-dependent process catalysed by a transcription factor.
    EMBO J. 1998 Dec 1;17(23):7044-55 PMID: 9843509
  26. AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes.
    Genome Res. 1999 Jan;9(1):27-43 PMID: 9927482
  27. Large T-antigen double hexamers imaged at the simian virus 40 origin of replication.
    Mol Cell Biol. 2000 Jan;20(1):34-41 PMID: 10594006
  28. The single minichromosome maintenance protein of Methanobacterium thermoautotrophicum DeltaH contains DNA helicase activity.
    Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14783-8 PMID: 10611290
  29. Two patches of amino acids on the E2 DNA binding domain define the surface for interaction with E1.
    J Virol. 2000 Feb;74(3):1506-12 PMID: 10627562
  30. Transcription factor-dependent loading of the E1 initiator reveals modular assembly of the papillomavirus origin melting complex.
    J Biol Chem. 2000 Feb 4;275(5):3522-34 PMID: 10652347
  31. A double-hexamer archaeal minichromosome maintenance protein is an ATP-dependent DNA helicase.
    Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1530-5 PMID: 10677495
  32. Premature structural changes at replication origins in a yeast minichromosome maintenance (MCM) mutant.
    J Biol Chem. 2000 Jun 16;275(24):18011-21 PMID: 10751424
  33. Isolation and characterization of various complexes of the minichromosome maintenance proteins of Schizosaccharomyces pombe.
    J Biol Chem. 2000 Jun 23;275(25):18871-8 PMID: 10770926
  34. MCM proteins in DNA replication.
    Annu Rev Biochem. 1999;68:649-86 PMID: 10872463
  35. Crystal structure of the DNA binding domain of the replication initiation protein E1 from papillomavirus.
    Mol Cell. 2000 Jul;6(1):149-58 PMID: 10949036
  36. Phosphorylation of simian virus 40 T antigen on Thr 124 selectively promotes double-hexamer formation on subfragments of the viral core origin.
    J Virol. 2000 Sep;74(18):8601-13 PMID: 10954562
  37. SV40 large T antigen functions in DNA replication and transformation.
    Adv Virus Res. 2000;55:75-134 PMID: 11050941
  38. Initiating DNA synthesis: from recruiting to activating the MCM complex.
    J Cell Sci. 2001 Apr;114(Pt 8):1447-54 PMID: 11282021
  39. Interactions between two catalytically distinct MCM subgroups are essential for coordinated ATP hydrolysis and DNA replication.
    Mol Cell. 2001 Nov;8(5):1093-104 PMID: 11741544
  40. Crystal structures of two intermediates in the assembly of the papillomavirus replication initiation complex.
    EMBO J. 2002 Mar 15;21(6):1487-96 PMID: 11889054
  41. The mcm5-bob1 bypass of Cdc7p/Dbf4p in DNA replication depends on both Cdk1-independent and Cdk1-dependent steps in Saccharomyces cerevisiae.
    Genetics. 2002 May;161(1):47-57 PMID: 12019222
  42. A rotary pumping model for helicase function of MCM proteins at a distance from replication forks.
    EMBO Rep. 2003 Jan;4(1):26-30 PMID: 12524516
  43. Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture.
    J Biol Chem. 2003 Feb 14;278(7):4491-9 PMID: 12480933
  44. The structure and function of MCM from archaeal M. Thermoautotrophicum.
    Nat Struct Biol. 2003 Mar;10(3):160-7 PMID: 12548282
  45. Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen.
    Nature. 2003 May 29;423(6939):512-8 PMID: 12774115
  46. Initiation of DNA replication: lessons from viral initiator proteins.
    Nat Rev Mol Cell Biol. 2003 Oct;4(10):777-85 PMID: 14504622
  47. Hexameric ring structure of the full-length archaeal MCM protein complex.
    EMBO Rep. 2003 Nov;4(11):1079-83 PMID: 14566326
  48. Large T antigen on the simian virus 40 origin of replication: a 3D snapshot prior to DNA replication.
    EMBO J. 2003 Dec 1;22(23):6205-13 PMID: 14633980
  49. The crystal structure of the bifunctional primase-helicase of bacteriophage T7.
    Mol Cell. 2003 Nov;12(5):1113-23 PMID: 14636571
  50. Interactions required for binding of simian virus 40 T antigen to the viral origin and molecular modeling of initial assembly events.
    J Virol. 2004 Mar;78(6):2921-34 PMID: 14990710
  51. Eukaryotic MCM proteins: beyond replication initiation.
    Microbiol Mol Biol Rev. 2004 Mar;68(1):109-31 PMID: 15007098
  52. Dynamics of pre-replication complex proteins during the cell division cycle.
    Philos Trans R Soc Lond B Biol Sci. 2004 Jan 29;359(1441):7-16 PMID: 15065651
  53. Preformed hexamers of SV40 T antigen are active in RNA and origin-DNA unwinding.
    Nucleic Acids Res. 2002 Jul 15;30(14):3192-201 PMID: 12136101
  54. The Methanobacterium thermoautotrophicum MCM protein can form heptameric rings.
    EMBO Rep. 2002 Aug;3(8):792-7 PMID: 12151340
  55. Chaperone proteins abrogate inhibition of the human papillomavirus (HPV) E1 replicative helicase by the HPV E2 protein.
    Mol Cell Biol. 2002 Sep;22(18):6592-604 PMID: 12192057
  56. Characterization of simian virus 40 T-antigen double hexamers bound to a replication fork. The active form of the helicase.
    J Biol Chem. 2002 Nov 22;277(47):44886-97 PMID: 12244108
  57. Biochemical and electron microscopic image analysis of the hexameric E1 helicase.
    J Biol Chem. 1999 Feb 12;274(7):4447-58 PMID: 9933649
  58. The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2.
    Genes Dev. 2004 Aug 15;18(16):1981-96 PMID: 15289463
Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
0890-9369
DOI
10.1101/gad.1240604
Published
2004-09-01
Pages
2039-45
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC2292464
Subset
IM
Grants
NIGMS NIH HHS · R01 GM035078-15A2 · United States
NIGMS NIH HHS · R01 GM035078 · United States
NIGMS NIH HHS · R01 GM035078-16 · United States
NIGMS NIH HHS · R01 GM035078-17 · United States
NIGMS NIH HHS · R01 GM035078-18 · United States
External Links
PubMed source DOI: 10.1101/gad.1240604 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2