Food for thought: essential fatty acid protects against neuronal deficits in transgenic mouse model of AD.

Neuron ·Vol. 43 ·No. 5 ·2004-09-02 ·Pages 596-9

Mucke L, Pitas RE

Abstract

Interactions between environmental and genetic factors may contribute to neurodegenerative disease. In this issue of Neuron, Calon et al. report that a diet low in an essential omega-3 polyunsaturated fatty acid (docosahexaenoic acid) depletes postsynaptic proteins and exacerbates behavioral alterations in a transgenic mouse model of Alzheimer's disease.

MeSH Terms

Alzheimer Disease/genetics,metabolism,physiopathology Animals Brain/metabolism,pathology,physiopathology Disease Models, Animal Docosahexaenoic Acids/metabolism Humans Mice Mice, Transgenic/genetics,metabolism Nerve Tissue Proteins/metabolism Neuroprotective Agents/metabolism,therapeutic use Oxidative Stress/genetics

Chemicals

Nerve Tissue Proteins Neuroprotective Agents Docosahexaenoic Acids

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Mucke Lennart

Gladstone Institute of Neurological Disease, University of California, San Francisco, PO Box 419100, 94103, USA.

Pitas Robert E

Article Info

Journal

Neuron

Abbr.

Neuron

ISSN

0896-6273

DOI

10.1016/j.neuron.2004.08.025

Published

2004-09-02

Pages

596-9

Language

English

Region

United States

NLM ID

8809320

Subset

Corrections

CommentOn

PMID: 15339646

External Links

PubMed source DOI: 10.1016/j.neuron.2004.08.025 View journal details

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Food for thought: essential fatty acid protects against neuronal deficits in transgenic mouse model of AD.

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