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PMID: 15333743 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Fatty acid binding proteins--the evolutionary crossroads of inflammatory and metabolic responses.

The Journal of nutrition ·Vol. 134 ·No. 9 ·2004-09-00 ·Pages 2464S-2468S

Makowski L, Hotamisligil GS

Abstract

Fatty acid binding proteins (FABPs) are members of a highly conserved family of proteins with the task of protecting a cell's delicate lipid balance. Yet they fail when faced with metabolic or inflammatory stress, turning the cytosol into an inhospitable environment with less than ideal outcomes. This review will focus on how FABPs direct lipid traffic and simultaneously control inflammatory and metabolic pathways under the pressures of the Metabolic Syndrome.

MeSH Terms
Animals Carrier Proteins/metabolism Fatty Acid-Binding Proteins Humans Inflammation/metabolism Lipid Metabolism Metabolic Syndrome/metabolism
Chemicals
Carrier Proteins Fatty Acid-Binding Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Makowski Liza
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA, USA.
Hotamisligil Gökhan S
References (55)
55 references, click to expand
  1. Requirement for the heart-type fatty acid binding protein in cardiac fatty acid utilization.
    FASEB J. 1999 May;13(8):805-12 PMID: 10224224
  2. Targeted disruption of the adipocyte lipid-binding protein (aP2 protein) gene impairs fat cell lipolysis and increases cellular fatty acid levels.
    J Lipid Res. 1999 May;40(5):967-72 PMID: 10224167
  3. PPARgamma, the ultimate thrifty gene.
    Diabetologia. 1999 Sep;42(9):1033-49 PMID: 10447513
  4. Impaired long-chain fatty acid utilization by cardiac myocytes isolated from mice lacking the heart-type fatty acid binding protein gene.
    Circ Res. 1999 Aug 20;85(4):329-37 PMID: 10455061
  5. Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice.
    Diabetes. 1999 Oct;48(10):1987-94 PMID: 10512363
  6. Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm.
    Biochim Biophys Acta. 1999 Oct 18;1441(1):4-13 PMID: 10526223
  7. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone.
    N Engl J Med. 1994 Nov 3;331(18):1188-93 PMID: 7935656
  8. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase.
    Nature. 2000 Jan 6;403(6765):103-8 PMID: 10638762
  9. 15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway.
    Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4844-9 PMID: 10781090
  10. Series introduction: the molecular and physiological basis of insulin resistance: emerging implications for metabolic and cardiovascular diseases.
    J Clin Invest. 2000 Jul;106(2):163-4 PMID: 10903328
  11. Insulin resistance and cardiovascular disease.
    J Clin Invest. 2000 Aug;106(4):453-8 PMID: 10953019
  12. Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice.
    J Clin Invest. 2000 Aug;106(4):523-31 PMID: 10953027
  13. Improved glucose and lipid metabolism in genetically obese mice lacking aP2.
    Endocrinology. 2000 Sep;141(9):3388-96 PMID: 10965911
  14. Function of GATA transcription factors in preadipocyte-adipocyte transition.
    Science. 2000 Oct 6;290(5489):134-8 PMID: 11021798
  15. The intestinal fatty acid binding protein is not essential for dietary fat absorption in mice.
    FASEB J. 2000 Oct;14(13):2040-6 PMID: 11023988
  16. Lipid-binding proteins modulate ligand-dependent trans-activation by peroxisome proliferator-activated receptors and localize to the nucleus as well as the cytoplasm.
    J Lipid Res. 2000 Nov;41(11):1740-51 PMID: 11060343
  17. Oxidized LDL induces the expression of ALBP/aP2 mRNA and protein in human THP-1 macrophages.
    J Lipid Res. 2000 Dec;41(12):2017-23 PMID: 11108735
  18. Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha - and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus.
    Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2323-8 PMID: 11226238
  19. Atherosclerosis. the road ahead.
    Cell. 2001 Feb 23;104(4):503-16 PMID: 11239408
  20. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis.
    Nat Med. 2001 Jun;7(6):699-705 PMID: 11385507
  21. Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes.
    J Clin Invest. 2001 Jul;108(1):15-23 PMID: 11435451
  22. Prevention of fat-induced insulin resistance by salicylate.
    J Clin Invest. 2001 Aug;108(3):437-46 PMID: 11489937
  23. 15-Deoxy-Delta 12,14-prostaglandin J2 inhibition of NF-kappaB-DNA binding through covalent modification of the p50 subunit.
    J Biol Chem. 2001 Sep 21;276(38):35530-6 PMID: 11466314
  24. Nuclear receptors and lipid physiology: opening the X-files.
    Science. 2001 Nov 30;294(5548):1866-70 PMID: 11729302
  25. PPARgamma activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes.
    Biochem Biophys Res Commun. 1999 Aug 2;261(2):456-8 PMID: 10425206
  26. A role for preadipocytes as macrophage-like cells.
    FASEB J. 1999 Feb;13(2):305-12 PMID: 9973318
  27. Atherosclerosis--an inflammatory disease.
    N Engl J Med. 1999 Jan 14;340(2):115-26 PMID: 9887164
  28. Characterization of the functional interaction of adipocyte lipid-binding protein with hormone-sensitive lipase.
    J Biol Chem. 2001 Dec 28;276(52):49443-8 PMID: 11682468
  29. Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta(12,14)-prostaglandin J(2) ameliorates experimental autoimmune encephalomyelitis.
    J Immunol. 2002 Mar 1;168(5):2508-15 PMID: 11859145
  30. Insulin signalling and the regulation of glucose and lipid metabolism.
    Nature. 2001 Dec 13;414(6865):799-806 PMID: 11742412
  31. Prostaglandins and leukotrienes: advances in eicosanoid biology.
    Science. 2001 Nov 30;294(5548):1871-5 PMID: 11729303
  32. Dietary polyunsaturated fatty acids and regulation of gene transcription.
    Curr Opin Lipidol. 2002 Apr;13(2):155-64 PMID: 11891418
  33. 15-deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processes.
    J Biol Chem. 2002 Mar 22;277(12):10459-66 PMID: 11786541
  34. Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription.
    Mol Cell Biol. 2002 Jul;22(14):5114-27 PMID: 12077340
  35. SREBP-1: gene regulatory key to syndrome X?
    Ann N Y Acad Sci. 2002 Jun;967:19-27 PMID: 12079831
  36. Protein kinase C and lipid-induced insulin resistance in skeletal muscle.
    Ann N Y Acad Sci. 2002 Jun;967:146-57 PMID: 12079844
  37. Different genes, different diabetes: lessons from maturity-onset diabetes of the young.
    Ann Med. 2002;34(3):207-16 PMID: 12173691
  38. New insights into the structure and function of fatty acid-binding proteins.
    Cell Mol Life Sci. 2002 Jul;59(7):1096-116 PMID: 12222958
  39. Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia.
    Arterioscler Thromb Vasc Biol. 2002 Oct 1;22(10):1686-91 PMID: 12377750
  40. The adipocyte lipid binding protein (ALBP/aP2) gene facilitates foam cell formation in human THP-1 macrophages.
    Atherosclerosis. 2002 Dec;165(2):259-69 PMID: 12417276
  41. A central role for JNK in obesity and insulin resistance.
    Nature. 2002 Nov 21;420(6913):333-6 PMID: 12447443
  42. Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.
    J Biol Chem. 2002 Dec 13;277(50):48115-21 PMID: 12351658
  43. Analysis on the phenotype of E-FABP-gene knockout mice.
    Mol Cell Biochem. 2002 Oct;239(1-2):83-6 PMID: 12479572
  44. Role of the fatty acid binding protein mal1 in obesity and insulin resistance.
    Diabetes. 2003 Feb;52(2):300-7 PMID: 12540600
  45. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors.
    Nat Med. 2003 Feb;9(2):213-9 PMID: 12524534
  46. Preadipocyte conversion to macrophage. Evidence of plasticity.
    J Biol Chem. 2003 Mar 14;278(11):9850-5 PMID: 12519759
  47. Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.
    Nature. 2003 Mar 13;422(6928):173-6 PMID: 12629551
  48. Decreased liver fatty acid binding capacity and altered liver lipid distribution in mice lacking the liver fatty acid-binding protein gene.
    J Biol Chem. 2003 Jun 13;278(24):21429-38 PMID: 12670956
  49. Role of PPARs in the regulation of obesity-related insulin sensitivity and inflammation.
    Int J Obes Relat Metab Disord. 2003 Dec;27 Suppl 3:S17-21 PMID: 14704738
  50. mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.
    Genes Dev. 1994 May 15;8(10):1224-34 PMID: 7926726
  51. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein.
    Science. 1996 Nov 22;274(5291):1377-9 PMID: 8910278
  52. A molecular aspect of hematopoiesis and endoderm development common to vertebrates and Drosophila.
    Development. 1996 Dec;122(12):4023-31 PMID: 9012522
  53. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation.
    Nature. 1998 Jan 1;391(6662):79-82 PMID: 9422508
  54. Differential influence of rat liver fatty acid binding protein isoforms on phospholipid fatty acid composition: phosphatidic acid biosynthesis and phospholipid fatty acid remodeling.
    Biochim Biophys Acta. 1998 Feb 23;1390(3):258-68 PMID: 9487147
  55. Physiological properties and functions of intracellular fatty acid-binding proteins.
    Biochim Biophys Acta. 1998 Apr 22;1391(3):287-306 PMID: 9555061
Article Info
Journal
The Journal of nutrition
Abbr.
J Nutr
ISSN
0022-3166
DOI
10.1093/jn/134.9.2464S
Published
2004-09-00
Pages
2464S-2468S
Language
English
Region
United States
NLM ID
0404243
PMCID
PMC4027055
Subset
IM
Grants
NHLBI NIH HHS · F32 HL075970 · United States
External Links
PubMed source DOI: 10.1093/jn/134.9.2464S PMC Full Text View journal details
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