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题目:: Folate-conjugated liposomes preferentially target macrophages associated with ovarian carcinoma.
作者:: Turk(Mary Jo),Waters(David J),Low(Philip S)
状态:: 发布时间2004-08-25 , 更新时间 2013-11-21
期刊:: Cancer Lett
摘要:: The folate receptor (FR) is overexpressed on many epithelial cancers and has been exploited for targeted delivery of folate-linked liposomes to cancer cells in vitro. The present studies investigate the distribution of folate-targeted liposomes in a FR(+) mouse model of ovarian cancer. According to flow cytometric analysis, folate-conjugation of liposomes significantly enhanced their uptake into ovarian cancer cells and tumor-associated macrophages within tumor ascites fluid. Compared to ovarian cancer cells, macrophages acquired tenfold more liposomes, and approximately 50% of this uptake was FR-dependent. These results demonstrate that, in addition to their cancer cell-targeting properties, folate-liposomes may be useful for targeting drugs to tumor-associated macrophages in vivo.
语言:: eng
DOI:

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