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PMID: 15322544 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Genomic segmental polymorphisms in inbred mouse strains.

Nature genetics ·Vol. 36 ·No. 9 ·2004-09-00 ·Pages 952-4

Li J, Jiang T, Mao JH, Balmain A, Peterson L, Harris C, Rao PH, Havlak P, Gibbs R, Cai WW

Abstract

By analyzing genomic copy-number differences using high-resolution mouse whole-genome BAC arrays, we uncover substantial differences in regional DNA content between inbred strains of mice. The identification of these apparently common segmental polymorphisms suggests that these differences can contribute to genetic variability and pathologic susceptibility.

MeSH Terms

Animals Base Sequence Chromosomes, Artificial, Bacterial Gene Dosage In Situ Hybridization, Fluorescence Mice Mice, Inbred Strains/genetics Polymorphism, Genetic

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Li Jiangzhen

Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.

Jiang Tao

Mao Jian-Hua

Balmain Allan

Peterson Leif

Harris Charles

Rao Pulivarthi H

Havlak Paul

Gibbs Richard

Cai Wei-Wen

Article Info

Journal

Nature genetics

Abbr.

Nat Genet

ISSN

1061-4036

DOI

10.1038/ng1417

Published

2004-09-00

Epub

2004-00-22

Pages

952-4

Language

English

Region

United States

NLM ID

9216904

Subset

External Links

PubMed source DOI: 10.1038/ng1417 View journal details

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