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PMID: 15322048 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Characterization of binding of Streptococcus oralis glyceraldehyde-3-phosphate dehydrogenase to Porphyromonas gingivalis major fimbriae.

Infection and immunity ·Vol. 72 ·No. 9 ·2004-09-00 ·Pages 5475-7

Maeda K, Nagata H, Kuboniwa M, Kataoka K, Nishida N, Tanaka M, Shizukuishi S

Abstract

Binding of Streptococcus oralis glyceraldehyde-3-phosphate dehydrogenase (GAPDH) to Porphyromonas gingivalis fimbriae was characterized via a biomolecular interaction analysis system. The interaction was specific, and the association constant value was 4.34 x 10(7) M(-1), suggesting that S. oralis GAPDH functions as a dominant receptor for P. gingivalis and contributes to P. gingivalis colonization.

MeSH Terms
Biosensing Techniques Fimbriae Proteins/genetics,metabolism Fimbriae, Bacterial/metabolism Glyceraldehyde-3-Phosphate Dehydrogenases/genetics,metabolism Humans Kinetics Porphyromonas gingivalis/metabolism Streptococcus oralis/enzymology,metabolism
Chemicals
fimbrillin Fimbriae Proteins Glyceraldehyde-3-Phosphate Dehydrogenases
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Maeda Kazuhiko
Department of Preventive Dentistry, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan.
Nagata Hideki
Kuboniwa Masae
Kataoka Kosuke
Nishida Nobuko
Tanaka Muneo
Shizukuishi Satoshi
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.72.9.5475-5477.2004
Published
2004-09-00
Pages
5475-7
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC517434
Subset
IM
External Links
PubMed source DOI: 10.1128/IAI.72.9.5475-5477.2004 PMC Full Text View journal details
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