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PMID: 1530636 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Photosensitized formation of 8-hydroxydeoxyguanosine in cellular DNA by riboflavin.

Biochemical and biophysical research communications ·Vol. 187 ·No. 2 ·1992-09-16 ·Pages 809-13

Yamamoto F, Nishimura S, Kasai H

Abstract

Photosensitized formation of 8-hydroxydeoxyguanosine (oh8dG) in DNA by riboflavin has recently been shown in vitro. The present study describes the formation of oh8dG in cellular DNA by photo-irradiation of cultured mammalian cells in the presence of riboflavin. Formation of oh8dG was dependent on the concentration of riboflavin as well as the duration of photoirradiation. These results suggest that photosensitized formation of oh8dG in DNA by riboflavin may be involved in photocarcinogenesis.

MeSH Terms

8-Hydroxy-2'-Deoxyguanosine Animals Cell Line DNA/metabolism,radiation effects DNA Damage/radiation effects Deoxyguanosine/analogs & derivatives,metabolism Fibroblasts/metabolism Humans Light Lymphoma/metabolism Mice Riboflavin/pharmacology Tumor Cells, Cultured

Chemicals

8-Hydroxy-2'-Deoxyguanosine DNA Deoxyguanosine Riboflavin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Yamamoto F

Biology Division, National Cancer Center Research Institute, Tokyo, Japan.

Nishimura S

Kasai H

Article Info

Journal

Biochemical and biophysical research communications

Abbr.

Biochem Biophys Res Commun

ISSN

0006-291X

DOI

10.1016/0006-291x(92)91268-u

Published

1992-09-16

Pages

809-13

Language

English

Region

United States

NLM ID

0372516

Subset

External Links

PubMed source DOI: 10.1016/0006-291x(92)91268-u View journal details

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Photosensitized formation of 8-hydroxydeoxyguanosine in cellular DNA by riboflavin.

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