| GeneLibs

题目:: CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection.
作者:: Sun(Joseph C),Williams(Matthew A),Bevan(Michael J)
状态:: 发布时间2004-08-30 , 更新时间 2016-11-22
期刊:: Nat Immunol
摘要:: Immunization in the absence of CD4(+) T cell help results in defective CD8(+) T cell memory, deficient recall responses and diminished protective immunity. Here we investigated at what stage during the immune response to pathogen CD4(+) T cells are essential in the promotion of functional CD8(+) T cell memory. Memory CD8(+) T cell numbers decreased gradually in the absence of CD4(+) T cells despite the presence of similar numbers of memory cell precursors at the peak of the effector phase. Adoptive transfer of effector or memory CD8(+) T cells into wild-type or CD4(+) T cell-deficient mice demonstrated that the presence of CD4(+) T cells was important only after, not during, the early CD8(+) T cell programming phase. In the absence of CD4(+) T cells, memory CD8(+) T cells became functionally impaired and decreased in quantity over time. We conclude that in the context of an acute infection, CD4(+) T cells are required only during the maintenance phase of long-lived memory CD8(+) T cells.
语言:: eng
DOI:

文献库文献相关信息