Molecular biology: what ubiquitin can do for transcription.

Current biology : CB ·Vol. 14 ·No. 15 ·2004-08-10 ·Pages R622-4

Herrera FJ, Triezenberg SJ

Abstract

Ubiquitin, the peptide 'tag' that targets eukaryotic proteins for degradation by the proteasome, has also been implicated in transcriptional activation. The mechanism of gene activation might include recruitment of a transcriptional elongation factor by ubiquitinated activators.

MeSH Terms

Models, Biological Positive Transcriptional Elongation Factor B/metabolism RNA Polymerase II/metabolism Transcriptional Activation/physiology Ubiquitin/metabolism,physiology

Chemicals

Ubiquitin Positive Transcriptional Elongation Factor B RNA Polymerase II

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Herrera Francisco J

Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824-1319, USA.

Triezenberg Steven J

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/j.cub.2004.07.046

Published

2004-08-10

Pages

R622-4

Language

English

Region

England

NLM ID

9107782

Subset

Corrections

CommentOn

PMID: 15203006

External Links

PubMed source DOI: 10.1016/j.cub.2004.07.046 View journal details

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