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PMID: 15279795 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The emerging role of E2F-1 in the DNA damage response and checkpoint control.

DNA repair ·Vol. 3 ·No. 8-9 ·2004-00-00 ·Pages 1071-9

Stevens C, La Thangue NB

Abstract

Genotoxic stress triggers a myriad of cellular responses including cell cycle arrest, stimulation of DNA repair and apoptosis. A central role for the E2F-1 transcription factor in the DNA damage response pathway is gaining support. E2F-1 is phosphorylated by DNA damage responsive protein kinases, which leads to E2F-1 accumulation and the induction of apoptosis. In addition, emerging information suggests that E2F-1 may play a role in the detection and subsequent repair of damaged DNA.

MeSH Terms

Animals Apoptosis Cell Cycle Proteins/physiology DNA/metabolism DNA Damage DNA Repair DNA-Binding Proteins/physiology Dimerization E2F Transcription Factors E2F1 Transcription Factor Gene Expression Regulation Genome Humans Models, Biological Phosphorylation Transcription Factors/physiology Transcription, Genetic

Chemicals

Cell Cycle Proteins DNA-Binding Proteins E2F Transcription Factors E2F1 Transcription Factor E2F1 protein, human Transcription Factors DNA

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Stevens Craig

Division of Biochemistry and Molecular Biology, Davidson Building, University of Glasgow, Glasgow G12 8QQ, UK.

La Thangue Nicholas B

Article Info

Journal

DNA repair

Abbr.

DNA Repair (Amst)

ISSN

1568-7864

DOI

10.1016/j.dnarep.2004.03.034

Published

2004-00-00

Pages

1071-9

Language

English

Region

Netherlands

NLM ID

101139138

Subset

Grants

Cancer Research UK · 13058 · United Kingdom

Medical Research Council · G9400953 · United Kingdom

External Links

PubMed source DOI: 10.1016/j.dnarep.2004.03.034 View journal details

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The emerging role of E2F-1 in the DNA damage response and checkpoint control.

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