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PMID: 15271957 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Inactivation of the ciaH Gene in Streptococcus mutans diminishes mutacin production and competence development, alters sucrose-dependent biofilm formation, and reduces stress tolerance.

Infection and immunity ·Vol. 72 ·No. 8 ·2004-08-00 ·Pages 4895-9

Qi F, Merritt J, Lux R, Shi W

Abstract

Many clinical isolates of Streptococcus mutans produce peptide antibiotics called mutacins. Mutacin production may play an important role in the ecology of S. mutans in dental plaque. In this study, inactivation of a histidine kinase gene, ciaH, abolished mutacin production. Surprisingly, the same mutation also diminished competence development, stress tolerance, and sucrose-dependent biofilm formation.

MeSH Terms
Bacteriocins/biosynthesis Biofilms/growth & development Gene Deletion Heat-Shock Response Histidine Kinase Humans Hydrogen-Ion Concentration Protein Kinases/genetics,metabolism Streptococcus mutans/genetics,growth & development,metabolism,physiology Sucrose/metabolism
Chemicals
Bacteriocins mutacin I Sucrose Protein Kinases Histidine Kinase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Qi Fengxia
Department of Oral Biology and Molecualr Biology Institute, UCLA School of Dentistry, P.O. Box 951668, Los Angeles, CA 90095-1668, USA. fqi@dentnet.dent.ucla.edu
Merritt Justin
Lux Renate
Shi Wenyuan
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.72.8.4895-4899.2004
Email
fqi@dentnet.dent.ucla.edu
Published
2004-08-00
Pages
4895-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC470703
Subset
IM
Grants
NIDCR NIH HHS · R01 DE014757 · United States
NIAID NIH HHS · T32 AI007323 · United States
NIDCR NIH HHS · R01 DE 014757 · United States
NIAID NIH HHS · T32-AI07323 · United States
External Links
PubMed source DOI: 10.1128/IAI.72.8.4895-4899.2004 PMC Full Text View journal details
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