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PMID: 15259027 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Secretory phospholipase A2 induces dendritic cell maturation.

European journal of immunology ·Vol. 34 ·No. 8 ·2004-08-00 ·Pages 2293-302

Perrin-Cocon L, Agaugué S, Coutant F, Masurel A, Bezzine S, Lambeau G, André P, Lotteau V

Abstract

High level of phospholipase A(2) (PLA(2)) activity is found in serum and biological fluids during the acute-phase response (APR). Extracellular PLA(2) in fluids of patients with inflammatory diseases such as sepsis, acute pancreatitis or rheumatoid arthritis is also associated with propagation of inflammation. PLA(2) activity is involved in the release of both pro- and anti-inflammatory lipid mediators from phospholipids of cellular membranes or circulating lipoproteins. PLA(2) may thus generate signals that influence immune responses. Here, group III secretory PLA(2) were tested for their ability to promote generation of functionally mature human dendritic cells (DC). PLA(2) treatment of differentiating monocytes in the presence of granulocyte/macrophage colony-stimulating factor and IL-4 yielded cells with phenotypical and functional characteristics of mature DC. This maturation was dependent on the dose of PLA(2), and PLA(2)-generated DC stimulated IFN-gamma secretion by allogeneic T cells. The effects of PLA(2) on DC maturation was mainly dependent on enzyme activity and correlated with the activation of NF-kappaB, AP-1 and NFAT. The data suggest that transient increase in PLA(2) activity generates signals that promote transition of innate to adaptive immunity during the APR.

MeSH Terms
Catalytic Domain Cell Differentiation/immunology,physiology Dendritic Cells/enzymology,immunology,physiology Humans Phenotype Phospholipases A/metabolism Phospholipases A2 Transcription Factors/metabolism
Chemicals
Transcription Factors Phospholipases A Phospholipases A2
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Perrin-Cocon Laure
Institut Fédératif de Recherche 128, Institut National de la Santé et de la Recherche Médicale Unit 503, F-69365 Lyon Cedex 07, France.
Agaugué Sophie
Coutant Frédéric
Masurel Aurélie
Bezzine Sofiane
Lambeau Gérard
André Patrice
Lotteau Vincent
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Article Info
Journal
European journal of immunology
Abbr.
Eur J Immunol
ISSN
0014-2980
DOI
10.1002/eji.200324797
Published
2004-08-00
Pages
2293-302
Language
English
Region
Germany
NLM ID
1273201
PMCID
PMC2755771
Subset
IM
External Links
PubMed source DOI: 10.1002/eji.200324797 PMC Full Text View journal details
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