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PMID: 15247098 Published · ppublish English Evaluation Study Journal Article Research Support, U.S. Gov't, P.H.S.

DAGchainer: a tool for mining segmental genome duplications and synteny.

Bioinformatics (Oxford, England) ·Vol. 20 ·No. 18 ·2004-12-12 ·Pages 3643-6

Haas BJ, Delcher AL, Wortman JR, Salzberg SL

Abstract

Given the positions of protein-coding genes along genomic sequence and probability values for protein alignments between genes, DAGchainer identifies chains of gene pairs sharing conserved order between genomic regions, by identifying paths through a directed acyclic graph (DAG). These chains of collinear gene pairs can represent segmentally duplicated regions and genes within a single genome or syntenic regions between related genomes. Automated mining of the Arabidopsis genome for segmental duplications illustrates the use of DAGchainer.

MeSH Terms
Algorithms Arabidopsis/genetics Chromosome Mapping/methods Conserved Sequence Gene Duplication Sequence Alignment/methods Sequence Analysis, DNA/methods Sequence Homology, Nucleic Acid Software
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Haas Brian J
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. bhaas@tigr.org <bhaas@tigr.org>
Delcher Arthur L
Wortman Jennifer R
Salzberg Steven L
Article Info
Journal
Bioinformatics (Oxford, England)
Abbr.
Bioinformatics
ISSN
1367-4803
Published
2004-12-12
Epub
2004-00-09
Pages
3643-6
Language
English
Region
England
NLM ID
9808944
Subset
IM
Grants
NLM NIH HHS · R01-LM007938 · United States
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