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PMID: 15194805 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Human immunodeficiency virus type 1 (HIV-1) diversity at time of infection is not restricted to certain risk groups or specific HIV-1 subtypes.

Journal of virology ·Vol. 78 ·No. 13 ·2004-07-00 ·Pages 7279-83

Sagar M, Kirkegaard E, Long EM, Celum C, Buchbinder S, Daar ES, Overbaugh J

Abstract

African women frequently acquire several genetically distinct human immunodeficiency virus type 1 (HIV-1) variants from a heterosexual partner, whereas the acquisition of multiple variants appears to be rare in men. To determine whether newly infected individuals in other risk groups acquire genetically diverse viruses, we examined the viral envelope sequences in plasma samples from 13 women and 4 men from the United States infected with subtype B viruses and 10 men from Kenya infected with non-subtype B viruses. HIV-1 envelope sequences differed by more than 2% in three U.S. women, one U.S. man, and one Kenyan man near the time of seroconversion. These findings suggest that early HIV-1 genetic diversity is not exclusive to women from Africa or to infection with any particular HIV-1 subtype.

MeSH Terms
Female Gene Products, env/genetics Genetic Variation HIV Infections/virology HIV-1/classification,genetics,pathogenicity Heteroduplex Analysis Humans Kenya Male Molecular Sequence Data Risk Factors Sequence Analysis, DNA United States
Chemicals
Gene Products, env
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Sagar Manish
Division of Human Biology, Fred Hutchinson Cancer Research Center, and Department of Medicine, University of Washington, Seattle, USA.
Kirkegaard Erin
Long E Michelle
Celum Connie
Buchbinder Susan
Daar Eric S
Overbaugh Julie
References (34)
34 references, click to expand
  1. Consistent viral evolutionary changes associated with the progression of human immunodeficiency virus type 1 infection.
    J Virol. 1999 Dec;73(12):10489-502 PMID: 10559367
  2. The effect of drug-injection behavior on genetic evolution of HIV-1.
    J Infect Dis. 1999 Oct;180(4):1025-32 PMID: 10479127
  3. Position and degree of mismatches and the mobility of DNA heteroduplexes.
    Nucleic Acids Res. 2000 Jun 15;28(12):E69 PMID: 10871392
  4. In vivo analysis of human T-cell leukemia virus type 1 reverse transcription accuracy.
    J Virol. 2000 Oct;74(20):9525-31 PMID: 11000222
  5. Selection forces and constraints on retroviral sequence variation.
    Science. 2001 May 11;292(5519):1106-9 PMID: 11352065
  6. Homogeneous quasispecies in 16 out of 17 individuals during very early HIV-1 primary infection.
    AIDS. 2002 Jan 25;16(2):189-95 PMID: 11807302
  7. Virus population homogenization following acute human immunodeficiency virus type 1 infection.
    J Virol. 2002 Dec;76(23):11953-9 PMID: 12414937
  8. From RNA to quasispecies: a DNA polymerase with proofreading activity is highly recommended for accurate assessment of viral diversity.
    J Virol Methods. 2003 May;109(2):161-70 PMID: 12711059
  9. Infection with multiple human immunodeficiency virus type 1 variants is associated with faster disease progression.
    J Virol. 2003 Dec;77(23):12921-6 PMID: 14610215
  10. Primary infection of a male plasma donor with divergent HIV variants from the same source followed by rapid fluctuations in their relative frequency and viral recombination.
    AIDS Res Hum Retroviruses. 2003 Nov;19(11):1009-15 PMID: 14678608
  11. Identification of modifiable factors that affect the genetic diversity of the transmitted HIV-1 population.
    AIDS. 2004 Mar 5;18(4):615-9 PMID: 15090766
  12. Identification and characterization of conserved and variable regions in the envelope gene of HTLV-III/LAV, the retrovirus of AIDS.
    Cell. 1986 Jun 6;45(5):637-48 PMID: 2423250
  13. Selection, recombination, and G----A hypermutation of human immunodeficiency virus type 1 genomes.
    J Virol. 1991 Apr;65(4):1779-88 PMID: 2002543
  14. Selective transmission of human immunodeficiency virus type-1 variants from mothers to infants.
    Science. 1992 Feb 28;255(5048):1134-7 PMID: 1546316
  15. HIV-1 genomic RNA diversification following sexual and parenteral virus transmission.
    Virology. 1992 Jul;189(1):103-10 PMID: 1376536
  16. Selection for specific sequences in the external envelope protein of human immunodeficiency virus type 1 upon primary infection.
    J Virol. 1993 Jun;67(6):3345-56 PMID: 8497055
  17. Genotypic and phenotypic characterization of HIV-1 patients with primary infection.
    Science. 1993 Aug 27;261(5125):1179-81 PMID: 8356453
  18. Genetic relationships determined by a DNA heteroduplex mobility assay: analysis of HIV-1 env genes.
    Science. 1993 Nov 19;262(5137):1257-61 PMID: 8235655
  19. Human immunodeficiency virus type 1 evolution in vivo tracked by DNA heteroduplex mobility assays.
    J Virol. 1994 Oct;68(10):6672-83 PMID: 8084001
  20. Sequence diversity of V1 and V2 domains of gp120 from human immunodeficiency virus type 1: lack of correlation with viral phenotype.
    J Virol. 1995 Apr;69(4):2708-15 PMID: 7884929
  21. Diversity in virus populations from genital secretions and peripheral blood from women recently infected with human immunodeficiency virus type 1.
    J Virol. 1995 Dec;69(12):8118-22 PMID: 7494333
  22. Functional characterization of the V1V2 region of human immunodeficiency virus type 1.
    Virology. 1996 Jun 15;220(2):436-49 PMID: 8661394
  23. Distinct but related human immunodeficiency virus type 1 variant populations in genital secretions and blood.
    AIDS Res Hum Retroviruses. 1996 Jan 20;12(2):107-15 PMID: 8834460
  24. Lentiviral genomes with G-to-A hypermutation may result from Taq polymerase errors during polymerase chain reaction.
    AIDS Res Hum Retroviruses. 1996 Nov 20;12(17):1605-13 PMID: 8947295
  25. Primary infections with HIV-1 of women and their offspring in Rwanda: findings of heterogeneity at seroconversion, coinfection, and recombinants of HIV-1 subtypes A and C.
    Virology. 1997 Jan 6;227(1):63-76 PMID: 9007059
  26. Evolution of human immunodeficiency virus type 1 env sequence variation in patients with diverse rates of disease progression and T-cell function.
    J Virol. 1997 Mar;71(3):1871-9 PMID: 9032317
  27. Founder virus population related to route of virus transmission: a determinant of intrahost human immunodeficiency virus type 1 evolution?
    J Virol. 1997 Mar;71(3):2023-30 PMID: 9032334
  28. In vivo sequence variability of human immunodeficiency virus type 1 envelope gp120: association of V2 extension with slow disease progression.
    J Virol. 1997 Jul;71(7):4871-81 PMID: 9188549
  29. Slower evolution of human immunodeficiency virus type 1 quasispecies during progression to AIDS.
    J Virol. 1997 Oct;71(10):7498-508 PMID: 9311829
  30. Efficient isolation of human immunodeficiency virus type 1 RNA from cervical swabs.
    J Clin Microbiol. 1998 Aug;36(8):2349-52 PMID: 9666021
  31. Evolution of envelope sequences from the genital tract and peripheral blood of women infected with clade A human immunodeficiency virus type 1.
    J Virol. 1998 Oct;72(10):8240-51 PMID: 9733867
  32. Patterns of HIV-1 evolution in individuals with differing rates of CD4 T cell decline.
    Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12568-73 PMID: 9770526
  33. Hormonal contraception, sexually transmitted diseases, and risk of heterosexual transmission of human immunodeficiency virus type 1.
    J Infect Dis. 1998 Oct;178(4):1053-9 PMID: 9806034
  34. Gender differences in HIV-1 diversity at time of infection.
    Nat Med. 2000 Jan;6(1):71-5 PMID: 10613827
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.78.13.7279-7283.2004
Published
2004-07-00
Pages
7279-83
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC421693
Subset
IM
Grants
PHS HHS · I38518 · United States
NIAID NIH HHS · AI52759 · United States
NIAID NIH HHS · R37 AI038518 · United States
NIAID NIH HHS · U01 AI043638 · United States
NCRR NIH HHS · RR00425 · United States
NCRR NIH HHS · M01 RR000425 · United States
NIAID NIH HHS · AI43638 · United States
NIAID NIH HHS · K08 AI052759 · United States
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External Links
PubMed source DOI: 10.1128/JVI.78.13.7279-7283.2004 PMC Full Text View journal details
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