Brain proteome of mice lacking the receptors for tumor necrosis factor alpha.

Tumor necrosis factor alpha (TNF alpha) is involved in regulation of food intake, inflammatory response, and cancer cachexia. Its actions are mediated by at least two receptors: TNFR1 and TNFR2. We show that mice lacking the TNF alpha receptors have altered levels of proteins that take part in signal transduction, stress response, protein folding, glucose and amino acid metabolism, vesicle trafficking, and cytoskeletal arrangements. This is the first time that some of them have been associated with TNF alpha signaling pathways.