An invertebrate histocompatibility complex.
We have developed defined genetic lines of the hydroid Hydractinia symbiolongicarpus and confirmed earlier results showing that allorecognition is controlled by a single chromosomal region within these lines. In a large backcross population, we detected recombinants that display a fusibility phenotype distinct from typical fusion and rejection. We show that this transitory fusion phenotype segregates in a fashion expected of a single Mendelian trait, establishing that the chromosomal interval contains at least two genes that interact to determine fusibility. Using bulked segregant analysis, we have identified amplified fragment length polymorphisms (AFLP) cosegregating with fusibility, used these markers to independently confirm linkage of the two loci, and constructed a 3.4-cM map of an invertebrate histocompatibility complex.
13 references, click to expand
-
"Self-recognition" in colonial marine forms and flowering plants in relation to the evolution of immunity.Nature. 1971 Jul 23;232(5308):230-5 PMID: 4937075
-
The genetic control of histocompatibility reactions: phylogenetic aspects.Arch Biol (Liege). 1974;85(1):91-103 PMID: 4608165
-
Protochordate allorecognition is controlled by a MHC-like gene system.Nature. 1982 Feb 11;295(5849):499-502 PMID: 7057909
-
Somatic cell parasitism and the evolution of somatic tissue compatibility.Proc Natl Acad Sci U S A. 1982 Sep;79(17):5337-41 PMID: 6957867
-
Molecular identification and isolation of the Waxy locus in maize.Cell. 1983 Nov;35(1):225-33 PMID: 6313224
-
Histoincompatibility in vertebrates: the relict hypothesis.Dev Comp Immunol. 1985 Spring;9(2):191-201 PMID: 3894084
-
Mapping the genome of a model protochordate. I. A low resolution genetic map encompassing the fusion/histocompatibility (Fu/HC) locus of Botryllus schlosseri.Genetics. 1998 May;149(1):277-87 PMID: 9584102
-
Identification of markers linked to disease-resistance genes by bulked segregant analysis: a rapid method to detect markers in specific genomic regions by using segregating populations.Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9828-32 PMID: 1682921
-
Isolation of molecular markers from specific chromosomal intervals using DNA pools from existing mapping populations.Nucleic Acids Res. 1991 Dec 11;19(23):6553-8 PMID: 1684420
-
AFLP: a new technique for DNA fingerprinting.Nucleic Acids Res. 1995 Nov 11;23(21):4407-14 PMID: 7501463
-
Transmission genetics of allorecognition in Hydractinia symbiolongicarpus (Cnidaria:Hydrozoa).Genetics. 1996 Jun;143(2):823-7 PMID: 8725230
-
Is allorecognition specificity in Hydractinia symbiolongicarpus controlled by a single gene?Genetics. 1997 Mar;145(3):857-60 PMID: 9055094
-
MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations.Genomics. 1987 Oct;1(2):174-81 PMID: 3692487
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: product@genelibs.com
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
