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PMID: 15155238 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Fitness cost of SCCmec and methicillin resistance levels in Staphylococcus aureus.

Antimicrobial agents and chemotherapy ·Vol. 48 ·No. 6 ·2004-06-00 ·Pages 2295-7

Ender M, McCallum N, Adhikari R, Berger-Bächi B

Abstract

Transformation of a type I SCCmec element into Staphylococcus aureus yielded highly oxacillin-resistant transformants with a reduced growth rate. Faster-growing variants could again be selected at the cost of reduced resistance levels, demonstrating an inverse correlation between oxacillin resistance levels and growth rate.

MeSH Terms

Colony Count, Microbial DNA-Cytosine Methylases/genetics Electrophoresis, Gel, Pulsed-Field Interspersed Repetitive Sequences/genetics Methicillin Resistance/genetics Mutation/genetics Oxacillin/pharmacology Penicillins/pharmacology Plasmids/genetics Staphylococcus aureus/drug effects,genetics,growth & development Transformation, Bacterial/genetics

Chemicals

Penicillins DNA modification methylase XcyI DNA-Cytosine Methylases Oxacillin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Ender Miriam

Department of Medical Microbiology, University of Zürich, Gloriastr. 32, CH8028 Zürich, Switzerland.

McCallum Nadine

Adhikari Rajan

Berger-Bächi Brigitte

References (12)

12 references, click to expand

Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus.
Antimicrob Agents Chemother. 2001 May;45(5):1323-36 PMID: 11302791
Biological cost and compensatory evolution in fusidic acid-resistant Staphylococcus aureus.
Mol Microbiol. 2001 Apr;40(2):433-9 PMID: 11309125
Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community.
J Clin Microbiol. 2002 Nov;40(11):4289-94 PMID: 12409412
What makes resistance to methicillin heterogeneous?
J Med Microbiol. 2003 Aug;52(Pt 8):605-7 PMID: 12867551
Jumping the barrier to beta-lactam resistance in Staphylococcus aureus.
J Bacteriol. 2003 Sep;185(18):5465-72 PMID: 12949098
Eagle-type methicillin resistance: new phenotype of high methicillin resistance under mec regulator gene control.
Antimicrob Agents Chemother. 2001 Mar;45(3):815-24 PMID: 11181367
Mechanisms of heteroresistance in methicillin-resistant Staphylococcus aureus.
Antimicrob Agents Chemother. 1994 Apr;38(4):724-8 PMID: 8031036
Increase of methicillin resistance in Staphylococcus aureus caused by deletion of a gene whose product is homologous to lytic enzymes.
J Bacteriol. 1997 Oct;179(20):6294-301 PMID: 9335275
Teichoic acid content in different lineages of Staphylococcus aureus NCTC8325.
Arch Microbiol. 1998 Sep;170(3):171-8 PMID: 9683656
The biological cost of antibiotic resistance.
Curr Opin Microbiol. 1999 Oct;2(5):489-93 PMID: 10508723
A new class of genetic element, staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus.
Antimicrob Agents Chemother. 2000 Jun;44(6):1549-55 PMID: 10817707
In vivo stability of heterogeneous expression classes in clinical isolates of methicillin-resistant staphylococci.
J Infect Dis. 1991 Nov;164(5):883-7 PMID: 1940466

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.48.6.2295-2297.2004

Published

2004-06-00

Pages

2295-7

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC415608

Subset

External Links

PubMed source DOI: 10.1128/AAC.48.6.2295-2297.2004 PMC Full Text View journal details

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Fitness cost of SCCmec and methicillin resistance levels in Staphylococcus aureus.

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