Abstract
In breast tumours and breast cancer cell (BCC) lines, microarray analyses have revealed that a series of genes are expressed in close association with the oestrogen receptor-alpha (ER-alpha) gene, ESR1. Three of them, GATA3, HNF3A (also known as FOXA1), and XBP1 encode transcription factors. Here, we present these factors and we discuss their potential involvement in the ER-alpha-mediated actions in BCC. We notably show the relations that exist, or that might exist, between these factors and the oestrogen-inducible trefoil factor TFF1.
MeSH Terms
Base Sequence
Breast Neoplasms/genetics,metabolism
DNA-Binding Proteins/genetics,metabolism
Estrogen Receptor alpha/genetics,metabolism
Female
GATA3 Transcription Factor
Gene Expression Regulation, Neoplastic
Hepatocyte Nuclear Factor 3-alpha
Humans
Molecular Sequence Data
Nuclear Proteins/genetics,metabolism
Promoter Regions, Genetic/genetics
Proteins/genetics
Regulatory Factor X Transcription Factors
Trans-Activators/genetics,metabolism
Transcription Factors/genetics,metabolism
Trefoil Factor-1
Tumor Suppressor Proteins
X-Box Binding Protein 1
Chemicals
DNA-Binding Proteins
Estrogen Receptor alpha
FOXA1 protein, human
GATA3 Transcription Factor
GATA3 protein, human
Hepatocyte Nuclear Factor 3-alpha
Nuclear Proteins
Proteins
Regulatory Factor X Transcription Factors
TFF1 protein, human
Trans-Activators
Transcription Factors
Trefoil Factor-1
Tumor Suppressor Proteins
X-Box Binding Protein 1
XBP1 protein, human
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lacroix M
Laboratoire Jean-Claude Heuson de Cancérologie Mammaire, Institut Jules Bordet, Université Libre de Bruxelles, 127 Boulevard de Waterloo, B-1000 Bruxelles, Belgium. marc.lacroix@ulb.ac.be
Leclercq G