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PMID: 15149721 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

About GATA3, HNF3A, and XBP1, three genes co-expressed with the oestrogen receptor-alpha gene (ESR1) in breast cancer.

Molecular and cellular endocrinology ·Vol. 219 ·No. 1-2 ·2004-04-30 ·Pages 1-7

Lacroix M, Leclercq G

Abstract

In breast tumours and breast cancer cell (BCC) lines, microarray analyses have revealed that a series of genes are expressed in close association with the oestrogen receptor-alpha (ER-alpha) gene, ESR1. Three of them, GATA3, HNF3A (also known as FOXA1), and XBP1 encode transcription factors. Here, we present these factors and we discuss their potential involvement in the ER-alpha-mediated actions in BCC. We notably show the relations that exist, or that might exist, between these factors and the oestrogen-inducible trefoil factor TFF1.

MeSH Terms
Base Sequence Breast Neoplasms/genetics,metabolism DNA-Binding Proteins/genetics,metabolism Estrogen Receptor alpha/genetics,metabolism Female GATA3 Transcription Factor Gene Expression Regulation, Neoplastic Hepatocyte Nuclear Factor 3-alpha Humans Molecular Sequence Data Nuclear Proteins/genetics,metabolism Promoter Regions, Genetic/genetics Proteins/genetics Regulatory Factor X Transcription Factors Trans-Activators/genetics,metabolism Transcription Factors/genetics,metabolism Trefoil Factor-1 Tumor Suppressor Proteins X-Box Binding Protein 1
Chemicals
DNA-Binding Proteins Estrogen Receptor alpha FOXA1 protein, human GATA3 Transcription Factor GATA3 protein, human Hepatocyte Nuclear Factor 3-alpha Nuclear Proteins Proteins Regulatory Factor X Transcription Factors TFF1 protein, human Trans-Activators Transcription Factors Trefoil Factor-1 Tumor Suppressor Proteins X-Box Binding Protein 1 XBP1 protein, human
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lacroix M
Laboratoire Jean-Claude Heuson de Cancérologie Mammaire, Institut Jules Bordet, Université Libre de Bruxelles, 127 Boulevard de Waterloo, B-1000 Bruxelles, Belgium. marc.lacroix@ulb.ac.be
Leclercq G
Article Info
Journal
Molecular and cellular endocrinology
Abbr.
Mol Cell Endocrinol
ISSN
0303-7207
Published
2004-04-30
Pages
1-7
Language
English
Region
Ireland
NLM ID
7500844
Subset
IM
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