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PMID: 15143181 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Amphoterin stimulates myogenesis and counteracts the antimyogenic factors basic fibroblast growth factor and S100B via RAGE binding.

Molecular and cellular biology ·Vol. 24 ·No. 11 ·2004-06-00 ·Pages 4880-94

Sorci G, Riuzzi F, Arcuri C, Giambanco I, Donato R

Abstract

The receptor for advanced glycation end products (RAGE), a multiligand receptor of the immunoglobulin superfamily, has been implicated in the inflammatory response, diabetic angiopathy and neuropathy, neurodegeneration, cell migration, tumor growth, neuroprotection, and neuronal differentiation. We show here that (i) RAGE is expressed in skeletal muscle tissue and its expression is developmentally regulated and (ii) RAGE engagement by amphoterin (HMGB1), a RAGE ligand, in rat L6 myoblasts results in stimulation of myogenic differentiation via activation of p38 mitogen-activated protein kinase (MAPK), up-regulation of myogenin and myosin heavy chain expression, and induction of muscle creatine kinase. No such effects were detected in myoblasts transfected with a RAGE mutant lacking the transducing domain or myoblasts transfected with a constitutively inactive form of the p38 MAPK upstream kinase, MAPK kinase 6, Cdc42, or Rac-1. Moreover, amphoterin counteracted the antimyogenic activity of the Ca(2+)-modulated protein S100B, which was reported to inhibit myogenic differentiation via inactivation of p38 MAPK, and basic fibroblast growth factor (bFGF), a known inhibitor of myogenic differentiation, in a manner that was inversely related to the S100B or bFGF concentration and directly related to the extent of RAGE expression. These data suggest that RAGE and amphoterin might play an important role in myogenesis, accelerating myogenic differentiation via Cdc42-Rac-1-MAPK kinase 6-p38 MAPK.

MeSH Terms
Animals Calcium-Calmodulin-Dependent Protein Kinases/metabolism Fibroblast Growth Factor 2/metabolism HMGB1 Protein/metabolism MAP Kinase Kinase 6 Mitogen-Activated Protein Kinases/metabolism Muscle Development/physiology Muscle, Skeletal/metabolism Nerve Growth Factors/metabolism Rats Receptor for Advanced Glycation End Products Receptors, Immunologic/metabolism S100 Calcium Binding Protein beta Subunit S100 Proteins/metabolism cdc42 GTP-Binding Protein/metabolism p38 Mitogen-Activated Protein Kinases rac1 GTP-Binding Protein/metabolism
Chemicals
HMGB1 Protein Nerve Growth Factors Receptor for Advanced Glycation End Products Receptors, Immunologic S100 Calcium Binding Protein beta Subunit S100 Proteins S100b protein, rat Fibroblast Growth Factor 2 Calcium-Calmodulin-Dependent Protein Kinases Mitogen-Activated Protein Kinases p38 Mitogen-Activated Protein Kinases MAP Kinase Kinase 6 cdc42 GTP-Binding Protein rac1 GTP-Binding Protein
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Sorci Guglielmo
Department of Experimental Medicine and Biochemical Sciences, Section of Anatomy, University of Perugia, Via del Giochetto C.P. 81 Succ. 3, 06122 Perugia, Italy.
Riuzzi Francesca
Arcuri Cataldo
Giambanco Ileana
Donato Rosario
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/MCB.24.11.4880-4894.2004
Published
2004-06-00
Pages
4880-94
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC416409
Subset
IM
Grants
Telethon · 922 · Italy
External Links
PubMed source DOI: 10.1128/MCB.24.11.4880-4894.2004 PMC Full Text View journal details
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