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PMID: 15140829 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Putative ancestral origins of chromosomal segments in individual african americans: implications for admixture mapping.

Genome research ·Vol. 14 ·No. 6 ·2004-06-00 ·Pages 1076-84

Seldin MF, Morii T, Collins-Schramm HE, Chima B, Kittles R, Criswell LA, Li H

Abstract

Theoretically, markers that distinguish European from West African ancestry can be used to examine the origin of chromosomal segments in individual African Americans. In this study, putative ancestral origin was examined by using haplotypes estimated from genotyping 268 African Americans for 29 ancestry informative markers spaced over a 60-cM segment of chromosome 5. Analyses using a Bayesian algorithm (STRUCTURE) provided evidence that blocks of individual chromosomes derive from one or the other parental population. In addition, modeling studies were performed by using hidden real marker data to simulate patient and control populations under different genotypic risk ratios. Ancestry analysis showed significant results for a genotypic risk ratio of 2.5 in the African American population for modeled susceptibility genes derived from either putative parental population. These studies suggest that admixture mapping in the African American population can provide a powerful approach to defining genetic factors for some disease phenotypes.

MeSH Terms
African Americans/ethnology,genetics Blacks/genetics Chromosome Mapping Chromosomes, Human, Pair 5/genetics Computer Simulation Ethnicity/genetics Genetic Markers/genetics Genetic Variation/genetics Genetics, Population Genotype Haplotypes/genetics,immunology Humans Whites/genetics
Chemicals
Genetic Markers
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Seldin Michael F
Rowe Program in Human Genetics, Departments of Biological Chemistry and Medicine, University of California at Davis, Davis, California 95616-8669, USA. mfseldin@ucdavis.edu
Morii Takanobu
Collins-Schramm Heather E
Chima Bill
Kittles Rick
Criswell Lindsey A
Li Hongzhe
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Article Info
Journal
Genome research
Abbr.
Genome Res
ISSN
1088-9051
DOI
10.1101/gr.2165904
Email
mfseldin@ucdavis.edu
Published
2004-06-00
Epub
2004-00-12
Pages
1076-84
Language
English
Region
United States
NLM ID
9518021
PMCID
PMC419786
Subset
IM
Grants
NIDDK NIH HHS · U01 DK057249 · United States
NIAMS NIH HHS · AR20684 · United States
NIAMS NIH HHS · AR44804 · United States
NIDDK NIH HHS · U01-DK57249 · United States
External Links
PubMed source DOI: 10.1101/gr.2165904 PMC Full Text View journal details
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